Results 201 to 210 of about 68,587 (294)

Impact of osteoarthritis aetiology and implant constraint on the risk of secondary patellar resurfacing after total knee arthroplasty: An analysis of German Arthroplasty Registry (EPRD) data. [PDF]

J Exp Orthop
Kirschbaum S, Wu Y, Melsheimer O, Steinbrück A, Grimberg A.   +4 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Effectiveness of continuous pharmacist intervention at maintaining dose intensity in postoperative adjuvant S-1 chemotherapy for gastric cancer: a multicentre retrospective study. [PDF]

Int J Clin Pharm
Hayashi T, Go M, Kawasumi K, Kawakami K, Matsui R, Fujii H, Miyoshi T, Eto T, Kajizono M, Ohtsubo T, Morioka Y, Yamaguchi K, Ogawa A, Nakashima T, Todo M, Matsuo K.   +15 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Simultaneous multiple carpometacarpal joint dislocations with trapezium fracture and trapezoid dislocation: A case report. [PDF]

Trauma Case Rep
Mogi Y, Nishida K, Akane M, Kazuhiro U, Hideto I, Ho CY, Iida T.   +6 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

The social phenomenon of rare diseases: a logical-modal analysis. [PDF]

Front Sociol
Fernández-Vilas E, Coca JR, Plaza-Gómez N, Toscano FS.   +3 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Continuing Professional Development - Radiation Therapy. [PDF]

J Med Radiat Sci
europepmc   +1 more source