Results 61 to 70 of about 37,398 (266)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Polyelectrolyte-Stabilised Magnetic-Plasmonic Nanocomposites

open access: yesNanomaterials, 2018
In this work, new magnetic-plasmonic nanocomposites have been developed through the use of two complementary polyelectrolytes⁻polystyrene sulfonate (PSS) and poly(allylamine hydrochloride) (PAH).
Shelley Stafford   +2 more
doaj   +1 more source

Unsaturated Response of Clayey Soils Stabilised with Alkaline Cements

open access: yesMolecules, 2020
The influence of suction on the mechanical behaviour of unsaturated chemically stabilised soils is still mostly unknown and unquantified. This is also motivated by the difficulties associated with the experimental procedure required to fully characterise
Nuno Araújo   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Surgical stabilisation of the spine [PDF]

open access: yesSpinal Cord, 1975
It is important to assess spinal injuries, both in terms of cord damage and column damage, shortly after the trauma has occurred. A decision should then be made concerning the eventual stability of the bony vertebral column. If a lesion is unlikely to heal soundly by bone or if one is unable to obtain a reduction by conservative measures, one should ...
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Modelling and control of the roll-stabilised control unit of a rotary steerable system directional drilling tool

open access: yesThe Journal of Engineering, 2019
A directional drilling tool control unit whose design is based on servo control of a rotary valve using the roll-stabilised instrumented system approach has been successfully used in oil fields for over 20 years.
Hamid Alturbeh   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Effect of phosphogypsum on strength of lime stabilized expansive soil

open access: yesGrađevinar, 2014
The use of phosphogypsum as an additive to lime, to enhance its performance in soil stabilization, is analysed in this paper. The phosphogypsum is a by-product of the phosphate rock processing during production of phosphoric acid.
P. Kasinatha Pandian, Jijo James
doaj   +1 more source

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