Results 191 to 200 of about 37,398 (266)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Real-World Experience with Nintedanib in a Progressive Pulmonary Fibrosis Cohort. [PDF]

Medicina (Kaunas)
Vicens-Zygmunt V, Bordas-Martínez J, Muñoz-Bolaño M, Carmezim J, Llanos-González AB, Domingo-Carnice A, Rodríguez-Cumplido D, Bermudo-Peloche G, Tebé-Cordomí C, Peñafiel J, Llop-Rius R, Molina-Molina M.   +11 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Accessing chiral NHC-boranes by abstraction of C₆F₅ from the B(C₆F₅)₄^- weakly coordinating anion.

Dalton Trans
Niessen N, Adjieufack AI, Tumanov N, Wouters J, Champagne B, Berionni G, Bijouard K.   +6 more
europepmc   +1 more source

A prospective analysis of management and outcomes of worsening heart failure in the outpatient setting. [PDF]

ESC Heart Fail
McCambridge J, Fabamwo F, Taha S, McCaffrey D, Barrett M, Mahon C, McDonald K.   +6 more
europepmc   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Learning curve for robotic-assisted total knee arthroplasty. [PDF]

J Orthop Surg Res
Migliorini F, Schäfer L, Lucenti L, Schneider J, Nobili AM, Kämmer D, Maffulli N, Bell A.   +7 more
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Nanostructures as indicator for deformation dynamics. [PDF]

Nat Commun
Incel S, Ohl M, Aben F, Plümper O, Brantut N.   +4 more
europepmc   +1 more source

Correction: Sozarukova et al. Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeO₂ Nanoparticles. <i>Nanomaterials</i> 2024, <i>14,</i> 769. [PDF]

Nanomaterials (Basel)
Sozarukova MM, Kozlova TO, Beshkareva TS, Popov AL, Kolmanovich DD, Vinnik DA, Ivanova OS, Lukashin AV, Baranchikov AE, Ivanov VK.   +9 more
europepmc   +1 more source