Results 61 to 70 of about 55,649 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biopolymer Stabilised Earthen Construction Materials [PDF]
Earthen structures (i.e. structural units manufactured from soil) are often regarded as sustainable forms of construction due to their characteristically low carbon footprint.
MUGUDA-VISWANATH, SRAVAN +1 more
core
In this paper, stress-strain behaviour of sand-clay mixture stabilised with different cement and rice husk ash percentages, and reinforced with different polypropylene fibre lengths are evaluated.
Ali Ghorbani +3 more
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The chemistry of stabilised sulphonium ylides [PDF]
The review is devoted to the chemistry of stabilised sulphonium ylides, i. e. ylides with substituents at the carbanionic carbon atom capable of delocalising its negative charge.
Belkin Y., Polezhaeva N.
core
Thermophysical properties of stabilised soil building blocks
The thermal conductivity of lime/cement stabilised hollow and plain earth blocks, produced from Sudanese soil with the Brepak Press, has been measured using the Guarded Hot Box method. The results give thermal conductivity values for oven dry samples at (
E.A. Adam +3 more
core +1 more source

