Results 51 to 60 of about 835,285 (264)

Stability Indicating Method for Polysorbate 80 in Protein Formulations

Journal of Chromatographic Science, 2020
Abstract Polysorbates (also known as “Tween”) are common components of protein formulations used to minimize protein adsorption and stabilize the protein. These nonionic surfactants are heterogenous mixtures of fatty acids with a complex reversed-phase profile due to the inhomogeneity of the polymers present. Polysorbates can be oxidized,
Gregory K, Webster, Jean C, Chang, Julie L, Heflin   +2 more
openaire   +2 more sources

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Stability Indicating RP-HPLC Method for Estimation of Fexofenadine Hydrochloride in Pharmaceutical Formulation

E-Journal of Chemistry, 2012
A stability-indicating HPLC method was developed and validated for the quantitative determination of fexofenadine in tablet dosage forms. An isocratic seperation was achieved using a Zorbax, Eclipse XBD, C-8 Column having 150 x 4.6 mm i.d., 5 µm particle
H. M. Nimje, Shital T. Nimje, R. J. Oswal, S. T. Bhamre   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Stability indicating RP-HPLC method development and validation for the determination of pyrimethamine in an oral paediatric suspension

Journal of Pharmaceutical and Biomedical Analysis Open
The aim of this study is to validate a high-performance liquid chromatography (HPLC) – UV assay method for a stability assay of an oral suspension of PYR developed for newborns.
Sahra Muhammad, Zoé Ribier, Guy Benoit, Joelle Bordenave   +3 more
doaj   +1 more source

A validated stability indicating DAD–HPLC method for determination of pentoxifylline in presence of its pharmacopeial related substances

Bulletin of Faculty of Pharmacy Cairo University, 2013
A validated, simple and sensitive stability-indicating HPLC method was introduced for the analysis of Pentoxifylline in the presence of its pharmacopeial related substances, Caffeine anhydrous and Theophylline anhydrous, in the presence of its forced ...
Mohamed A. Korany, Rim S. Haggag, Marwa A.A. Ragab, Osama A. Elmallah   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Stability Indicating Methods for the Determination of Norfloxacin in Mixture with Tinidazole

Chemical and Pharmaceutical Bulletin, 2007
Three stability indicating assay methods are developed for the determination of norfloxacin (Nor) in the presence of its decarboxylated degradation product and in mixture with tinidazole (Tnd). The proposed methods are reversed phase ion pair liquid chromatography (LC), thin layer densitometry (TLC) and second derivative ratio spectra zero crossing ...
Mohammad, Mohammad Abdul-Azim, Zawilla, Nagwan Hamdy, El-Anwar, Fawzy Mohammad, El-Moghazy Aly, Samir Mohammad   +3 more
openaire   +3 more sources