Results 91 to 100 of about 10,939,833 (368)
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Nature Communications, 2017 DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome
Fernando Gómez-Herreros +6 more
doaj +1 more source
Scientific Reports, 2023 Mapping of landslides over space has seen an increasing attention and good results in the last decade. While current methods are chiefly applied to generate event-inventories, whereas multi-temporal (MT) inventories are rare, even using manual landslide ...
Kushanav Bhuyan +7 more
doaj +1 more source
Stability chart of the triangular points in the elliptic restricted problem of three bodies
, 2013 The possible observations of Trojan-like extrasolar planets stimulate the deeper understanding of the stability behaviour of the co-orbital resonant motion.
Kovacs, Tamas
core +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress
Nature CommunicationsTranscription generates superhelical stress in DNA that poses problems for genome stability, but determining when and where such stress arises within chromosomes is challenging. Here, using G1-arrested S.
William H. Gittens +4 more
doaj +1 more source
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
Nature Communications, 2016 Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy +12 more
doaj +1 more source
Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants [PDF]
PeerJ, 2016 Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers.
Olga V. Stepanenko +5 more
doaj +2 more sources
Role of anisotropy in determining stability of electrodeposition at solid-solid interfaces
, 2017 We investigate the stability of electrodeposition at solid-solid interfaces for materials exhibiting an anisotropic mechanical response. The stability of electrodeposition or resistance to the formation of dendrites is studied within a linear stability ...
Ahmad, Zeeshan +1 more
core +1 more source
The equivalence ofB-stability andA-stability
BIT, 1984 It is well known that linear and nonlinear stability concepts are equivalent for linear multistep methods in their one-leg formulation. This result is extended to Runge-Kutta methods. In particular, it is shown here that given an irreducible rational function R(z) whose degrees of numerator and denominator are at most s which has order of approximation
H. Türke +3 more
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source