Results 81 to 90 of about 7,887,454 (271)

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

open access: yesNature Communications, 2016
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy   +12 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Networks and farsighted stability [PDF]

open access: yes, 2001
We make two main contributions to the theory of economic and social network formation. First, we introduce the notion of a network formation network or a supernetwork.
Kamat, Samir   +2 more
core   +5 more sources

On the Stability of Random Multiple Access with Feedback Exploitation and Queue Priority

open access: yes, 2014
In this paper, we study the stability of two interacting queues under random multiple access in which the queues leverage the feedback information. We derive the stability region under random multiple access where one of the two queues exploits the ...
Seddik, Karim G.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

open access: yesEMBO Reports
Cyclosporin A (CsA) induces DNA double-strand breaks in LIG4 syndrome fibroblasts, specifically upon transit through S-phase. The basis underlying this has not been described.
Marisa Bedir   +5 more
doaj   +1 more source

Quasistaticity of the process of dynamic strain of soils

open access: yesИнженерно-строительный журнал, 2019
Mechanical characteristics of soil under static and dynamic strains are determined experimentally. Their accuracy and reliability depends on quasi-static nature of strain process in soil.
Karim Sultanov   +3 more
doaj   +1 more source

Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

open access: yesNature Communications, 2020
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett   +7 more
doaj   +1 more source

Does eductive stability imply evolutionary stability? [PDF]

open access: yes
This note presents a simple example of a model in which the unique rational expectations (RE) steady state equilibrium is eductively stable in the sense of Guesnerie (2002), but where evolutionary learning, as introduced in Brock and Hommes (1997), does ...
Hommes, C.H., Wagener, F.O.O.
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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