Results 61 to 70 of about 7,887,454 (271)

Stability of solitons in time-modulated two-dimensional lattices

, 2017
We develop stability analysis for matter-wave solitons in a two-dimensional (2D) Bose-Einstein condensate loaded in an optical lattice (OL), to which periodic time modulation is applied, in different forms.
Dror, Nir, Malomed, Boris A.
core   +1 more source

OnD-stability andB-stability

Numerische Mathematik, 1983
In this paper theD-stability properties of some classes of perturbed collocation methods are investigated. Among others we show the implicit Runge-Kutta methods described by Ehle-Chipman to beD-stable. We also give implicit Runge-Kutta methods that are bothD-stable andA-stable but notB-stable.
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Structural basis of Fanconi anemia pathway activation by FANCM

The EMBO Journal
FANCM is crucial in genome maintenance, functioning in the Fanconi anemia (FA) pathway, alternative lengthening of telomeres (ALT), and replication fork protection.
Rohan Bythell-Douglas, Sylvie van Twest, Lara Abbouche, Elyse Dunn, Rachel J Coulthard, David C Briggs, Vincent Murphy, Xinxin Zhang, Winnie Tan, Sarah S Henrikus, Dongming Qian, Yin Wu, Jana Wolf, Laurent Rigoreau, Shabih Shakeel, Kathryn L Chapman, Neil Q McDonald, Andrew J Deans   +17 more
doaj   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats

Nature Communications
DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation.
Michalis Amoiridis, John Verigos, Karen Meaburn, William H. Gittens, Tao Ye, Matthew J. Neale, Evi Soutoglou   +6 more
doaj   +1 more source

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

Nature Communications, 2017
DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome
Fernando Gómez-Herreros, Guido Zagnoli-Vieira, Ioanna Ntai, María Isabel Martínez-Macías, Rhona M. Anderson, Andrés Herrero-Ruíz, Keith W. Caldecott   +6 more
doaj   +1 more source

EU Fiscal Rules: A Look Back and the Way Forward

Intereconomics, 2022
The decline of “natural real interest rates” during the last three decades is a common phenomenon in all advanced economies and can be explained by a number of structural factors: the downward trend in potential growth; population ageing, which has led ...
Klaus Regling
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source