Results 21 to 30 of about 2,685,053 (297)

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

Nature Communications, 2019
Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens, Dominic J. Johnson, Rachal M. Allison, Tim J. Cooper, Holly Thomas, Matthew J. Neale   +5 more
doaj   +1 more source

PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

Nature Communications, 2019
The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones, Ankana Tiwari, Tomisin Olukoga, Alex Herbert, Kok-Lung Chan   +4 more
doaj   +1 more source

Genetic interaction between RLM1 and F-box motif encoding gene SAF1 contributes to stress response in Saccharomyces cerevisiae

Genes and Environment, 2021
Background Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress.
Meenu Sharma, V. Verma, Narendra K. Bairwa   +2 more
doaj   +1 more source

Forced vibrations of a box element of a multi-story building under dynamic impact

Magazine of Civil Engineering, 2022
The article is devoted to the dynamic calculations of the elements of the box-shaped structure of buildings for seismic resistance, taking into account the spatial work of the elements of the box under the action of dynamic influences set by the movement
Usarov Makhamatali, Mamatisaev Giyosiddin, Ayubov Gayratjon   +2 more
doaj   +1 more source

Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

Nature Communications, 2023
DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to ...
Wei Wu, Szymon A. Barwacz, Rahul Bhowmick, Katrine Lundgaard, Marisa M. Gonçalves Dinis, Malgorzata Clausen, Masato T. Kanemaki, Ying Liu   +7 more
doaj   +1 more source

Mathematical modeling of the kinematics of chemical droplets when pulverizing with a sprayer based on a new two-fluid turbulent model [PDF]

E3S Web of Conferences, 2021
A mathematical modeling and numerical solution of the motion of the droplets of chemical reagents outflowing from the pneumatic sprayer are developed in the article. A new efficient two-fluid turbulence model is used to simulate turbulent flow.
Malikov Zafar, Matchanov Rafik, Yuldashev Azamat, Djuraeva Nargiza   +3 more
doaj   +1 more source

From Design to Implementation: Addressing the Causes of Violent Conflict in Nigeria

Stability : International Journal of Security and Development, 2014
This article considers the ways in which knowledge and research influenced the design of a programme to reduce violent conflict in Nigeria. The diversity of sources and forms of conflict in Nigeria, and the way that local grievances interact ...
Judy El-Bushra, Sarah Ladbury, Ukoha Okorafor Ukiwo   +2 more
doaj   +1 more source

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

Nature Communications, 2016
Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy, Stuart L. Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W. Oliver, Laurence H. Pearl, Keith W. Caldecott   +7 more
doaj   +1 more source

To "stabilize'' or not to "stabilize"?

, 2002
The controversial question of whether or not an atom will be completely ionized by a laser pulse of arbitrarily increasing intensity is discussed.
Geltman, S., Fotino, M.
openaire   +2 more sources

The Stability study: a protocol for a multicenter randomized clinical trial comparing anterior cruciate ligament reconstruction with and without Lateral Extra-articular Tenodesis in individuals who are at high risk of graft failure

BMC Musculoskeletal Disorders, 2019
Background The purpose of anterior cruciate ligament reconstruction (ACLR) is to restore stability to the knee. Persistent rotational laxity following ACLR has been correlated with poor outcome and graft failure. We hypothesize that anterolateral complex
Alan Getgood, Dianne Bryant, Andrew Firth, Stability Group   +3 more
doaj   +1 more source