Results 21 to 30 of about 2,711,184 (322)

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

open access: yesNature Communications, 2018
Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA ...
Ankana Tiwari   +2 more
doaj   +1 more source

Modeling of vertical axis wind turbine using Ansys Fluent package program [PDF]

open access: yesE3S Web of Conferences, 2023
The paper considers a variant of the problem of modeling the flow around a developed wind turbine. Building a CAD model Fig. 1. was carried out in the SolidWorks environment, where the main geometric dimensions were specified.
Khujaev Ismatulla   +3 more
doaj   +1 more source

Regional Stability and Stability Radius [PDF]

open access: yesESAIM: Proceedings and Surveys, 2015
In this work we consider the problem of stability, for distributed parameter systems, through the space variable. We give an extension of the stability radius, introduced by A. J. Pritchard and S. Townley [7, 10], to the regional case. This consists to determine the “smallest disturbance” which destabilizes regionally an exponentially stable system. We
A. Bel Fekih, A. Bernoussi
openaire   +3 more sources

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

open access: yesNature Communications, 2019
Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens   +5 more
doaj   +1 more source

PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

open access: yesNature Communications, 2019
The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones   +4 more
doaj   +1 more source

Genetic interaction between RLM1 and F-box motif encoding gene SAF1 contributes to stress response in Saccharomyces cerevisiae

open access: yesGenes and Environment, 2021
Background Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress.
Meenu Sharma   +2 more
doaj   +1 more source

Forced vibrations of a box element of a multi-story building under dynamic impact

open access: yesMagazine of Civil Engineering, 2022
The article is devoted to the dynamic calculations of the elements of the box-shaped structure of buildings for seismic resistance, taking into account the spatial work of the elements of the box under the action of dynamic influences set by the movement
Usarov Makhamatali   +2 more
doaj   +1 more source

Stability Analysis of Nonlinear Time-Varying Systems by Lyapunov Functions with Indefinite Derivatives [PDF]

open access: yesIET Control Theory & Applications, 11(9): 1434-1442 (2017), 2015
This paper is concerned with stability analysis of nonlinear time-varying systems by using Lyapunov function based approach. The classical Lyapunov stability theorems are generalized in the sense that the time-derivative of the Lyapunov functions are allowed to be indefinite.
arxiv   +1 more source

From Design to Implementation: Addressing the Causes of Violent Conflict in Nigeria

open access: yesStability : International Journal of Security and Development, 2014
This article considers the ways in which knowledge and research influenced the design of a programme to reduce violent conflict in Nigeria. The diversity of sources and forms of conflict in Nigeria, and the way that local grievances interact ...
Judy El-Bushra   +2 more
doaj   +1 more source

Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

open access: yesNature Communications, 2023
DNA replication stress can generate under-replicated DNA regions which is fixed by an atypical form of DNA repair synthesis in mitosis (MiDAS). Here the authors show that translesion and replicative DNA polymerases cooperate via the POLD3 subunit to ...
Wei Wu   +7 more
doaj   +1 more source

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