Results 51 to 60 of about 5,611,319 (281)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
BuildingsMajor flood propagation processes often cause instability and damage to the ancient waterfront city walls. To quantitatively reveal the impact of major floods on the stability of ancient city walls, this paper takes Lanxi’s ancient city wall as a study ...
Zipeng Qin +6 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Global stability analysis and stabilization of power amplifiers [PDF]
2008 Microwaves, Radar and Remote Sensing Symposium, 2008 Power amplifiers often exhibit undesired behavior from certain input power value which cannot be predicted with a small-signal stability analysis. Among the commonly observed undesired phenomena are spurious oscillations, frequency divisions, hysteresis or chaos.
Suárez, Almudena +2 more
openaire +2 more sources
Stability Analysis in Magnetic Resonance Elastography II
, 2015 We consider the inverse problem of finding unknown elastic parameters from internal measurements of displacement fields for tissues. In the sequel to Ammari, Waters, Zhang (2015), we use pseudodifferential methods for the problem of recovering the shear ...
Gimperlein, Heiko, Waters, Alden
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Optimal allosteric stabilization sites using contact stabilization analysis [PDF]
Journal of Computational Chemistry, 2016 Proteins can be destabilized by a number of environmental factors such as temperature, pH, and mutation. The ability to subsequently restore function under these conditions by adding small molecule stabilizers, or by introducing disulfide bonds, would be a very powerful tool, but the physical principles that drive this stabilization are not well ...
Alex, Dickson +2 more
openaire +2 more sources
Stability analysis of perturbed plane Couette flow
, 1998 Plane Couette flow perturbed by a spanwise oriented ribbon, similar to a configuration investigated experimentally at the Centre d'Etudes de Saclay, is investigated numerically using a spectral-element code.
Cherhabili A. +2 more
core +4 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source