Results 71 to 80 of about 1,931,774 (264)

Stability and Ultimate Load of Three-Layered Plates – A Parametric Study

Engineering Transactions, 2003
This work deals with the analysis of influence of some geometrical and material parameters of layers on the mass, critical stress and ultimate load of three-layered plates. The plates are built of metal outer layers and a composite core.
R. Grądzki, K. Kowal-Michalska
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development and Evaluation of Egg-Free Mayonnaise Stabilized with Aquafaba and Gum Tragacanth: Functional, Sensory, and Storage Properties

Molecules
This study developed and evaluated plant-based mayonnaise formulations in which egg yolk was replaced with aquafaba (15–25%) and stabilized with gum tragacanth (0.3–1.0%).
Bakhtawar Shafique, Mian Anjum Murtaza, Muhammad Salman Farid, Kashif Ameer, Muhammad Imran Hussain, Monika Sienkiewicz, Anna Lichota, Łukasz Łopusiewicz   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Optimized Design of LCL Filter for Grid Tied Inverters With Deployment of Large-Scale Grid Connected PV System for Harmonics Compensation and Stable Operation Under Sudden Changes in Weather Conditions

IEEE Access
With the growing concerns about climate change and energy security, solar energy has been recognised as a green and reliable source of electrical energy. However, considering the variations of solar irradiance, particularly in Grid Connected Photovoltaic
Arjmand Khaliq, Hussin Zahloul, Hamed Hamzehbahmani, Sana Salous   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Optimal control and stability analysis of monkeypox transmission dynamics with the impact of contaminated surfaces

Frontiers in Applied Mathematics and Statistics
This study presents a comprehensive analysis of the transmission dynamics of monkeypox, considering contaminated surfaces using a deterministic mathematical model. The study begins by calculating the basic reproduction number and the stability properties
Abdullah Hasan Hassan, Dipo Aldila, Muhamad Hifzhudin Noor Aziz   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source