Results 81 to 90 of about 5,611,319 (281)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
MathematicsThis study establishes a fractional-order model (FOM) to describe the rumor spreading process. Members of society in this FOM are classified into three categories that change with time—the population that is ignorant of the rumors and does not know them,
Hegagi Mohamed Ali +2 more
doaj +1 more source
A Framework for Algorithm Stability [PDF]
, 2017 We say that an algorithm is stable if small changes in the input result in small changes in the output. This kind of algorithm stability is particularly relevant when analyzing and visualizing time-varying data.
Meulemans, Wouter +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Numerical Modeling of Levee Failure Mechanisms by Integrating Seepage and Stability Processes
GeoHazardsLevee failures caused by prolonged flooding and elevated upstream water levels pose a significant risk to floodplain communities, especially as the number of extreme hydrological events increases under climate change.
Liaqat Ali +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
WorldAgri-food supply chains have experienced notable changes in recent decades, with tomatoes (Solanum lycopersicum) maintaining their status as a key global crop in terms of both production and consumption.
Israel Benítez-García +8 more
doaj +1 more source
Stability and Ultimate Load of Three-Layered Plates – A Parametric Study
Engineering Transactions, 2003 This work deals with the analysis of influence of some geometrical and material parameters of layers on the mass, critical stress and ultimate load of three-layered plates. The plates are built of metal outer layers and a composite core.
R. Grądzki, K. Kowal-Michalska
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source