Results 81 to 90 of about 25,800,498 (305)
AppliedMathIn this article, we propose a nonlinear mathematical model that incorporates a discrete time delay. The model is used to analyze the dynamics of a socioeconomic system that includes economic growth, corruption, and unemployment.
Ogochukwu Ifeacho +1 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
MathematicsThis study establishes a fractional-order model (FOM) to describe the rumor spreading process. Members of society in this FOM are classified into three categories that change with time—the population that is ignorant of the rumors and does not know them,
Hegagi Mohamed Ali +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Numerical Modeling of Levee Failure Mechanisms by Integrating Seepage and Stability Processes
GeoHazardsLevee failures caused by prolonged flooding and elevated upstream water levels pose a significant risk to floodplain communities, especially as the number of extreme hydrological events increases under climate change.
Liaqat Ali +3 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
WorldAgri-food supply chains have experienced notable changes in recent decades, with tomatoes (Solanum lycopersicum) maintaining their status as a key global crop in terms of both production and consumption.
Israel Benítez-García +8 more
doaj +1 more source
Stability and Ultimate Load of Three-Layered Plates – A Parametric Study
Engineering Transactions, 2003 This work deals with the analysis of influence of some geometrical and material parameters of layers on the mass, critical stress and ultimate load of three-layered plates. The plates are built of metal outer layers and a composite core.
R. Grądzki, K. Kowal-Michalska
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source