Results 41 to 50 of about 824,222 (268)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The split step theta balanced numerical approximations of stochastic time varying Hopfield neural networks with distributed delays

Results in Control and Optimization, 2023
In this paper, split step theta balanced Euler approximations for stochastic time-varying delay Hopfield neural networks (HNN) with distributed delays are examined for their exponential stability and strong convergence.
Pichamuthu Mayavel, Anandaraman Rathinasamy   +1 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Extension of Cubic B-Spline for Solving the Time-Fractional Allen–Cahn Equation in the Context of Mathematical Physics

Computation
A B-spline is defined by the degree and quantity of knots, and it is observed to provide a higher level of flexibility in curve and surface layout. The extended cubic B-spline (ExCBS) functions with new approximation for second derivative and finite ...
Mubeen Fatima, Ravi P. Agarwal, Muhammad Abbas, Pshtiwan Othman Mohammed, Madiha Shafiq, Nejmeddine Chorfi   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Compact ADI Difference Scheme for the 2D Time Fractional Nonlinear Schrödinger Equation

Fractal and Fractional
In this paper, we will introduce a compact alternating direction implicit (ADI) difference scheme for solving the two-dimensional (2D) time fractional nonlinear Schrödinger equation.
Zulayat Abliz, Rena Eskar, Moldir Serik, Pengzhan Huang   +3 more
doaj   +1 more source

Stability and convergence of the Sasaki–Ricci flow [PDF]

Journal für die reine und angewandte Mathematik (Crelles Journal), 2014
AbstractWe introduce a holomorphic sheafℰ${\mathcal{E}}$on a Sasakian manifoldSand study two new notions of stability forℰ${\mathcal{E}}$along the Sasaki–Ricci flow related to the ‘jumping up’ of the number of global holomorphic sections ofℰ${\mathcal{E}}$at infinity.
openaire   +2 more sources

Einstein flow with matter sources: stability and convergence

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2022
Two recent articles (Moncrief V. 2015 InGeneral relativity and gravitation-A centennial perspective(eds A Asthekar, B Berger, J Isenberg, M MacCallum), pp. 480–498. Cambridge, UK: Cambridge University Press; Moncrief V, Mondal P. 2019Pure Appl. Math. Q.15, 921–965.
Vincent Moncrief, Puskar Mondal
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source