Results 41 to 50 of about 834,576 (285)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Numerical methods for hyperbolic differential functional problems [PDF]

Opuscula Mathematica, 2008
The paper deals with the initial boundary value problem for quasilinear first order partial differential functional systems. A general class of difference methods for the problem is constructed. Theorems on the error estimate of approximate solutions for
Roman Ciarski
doaj  

Stability of a force-based hybrid method with planar sharp interface

, 2014
We study a force-based hybrid method that couples atomistic model with Cauchy-Born elasticity model with sharp transition interface. We identify stability conditions that guarantee the convergence of the hybrid scheme to the solution of the atomistic ...
Lu, Jianfeng, Ming, Pingbing
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Convergence rate for a Gauss collocation method applied to constrained optimal control

, 2017
A local convergence rate is established for a Gauss orthogonal collocation method applied to optimal control problems with control constraints. If the Hamiltonian possesses a strong convexity property, then the theory yields convergence for problems ...
Hager, William W., Liu, Jun, Mohapatra, Subhashree, Rao, Anil V., Wang, Xiang-Sheng   +4 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Non integer order, discrete, state space model of heat transfer process using Grünwald-Letnikov operator [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019
The paper is intented to show a new, state space, discrete, non integer order model of a one-dimensional heat transfer process. The proposed model derives directly from time continuous, state space model and it uses the discrete Grünwald-Letnikov ...
K. Oprzędkiewicz, K. Dziedzic, Ł. Więckowski   +2 more
doaj   +1 more source

From Averaging to Acceleration, There is Only a Step-size [PDF]

, 2015
We show that accelerated gradient descent, averaged gradient descent and the heavy-ball method for non-strongly-convex problems may be reformulated as constant parameter second-order difference equation algorithms, where stability of the system is ...
Bach, Francis, Flammarion, Nicolas
core   +3 more sources

Stability and convergence of the Sasaki–Ricci flow [PDF]

Journal für die reine und angewandte Mathematik (Crelles Journal), 2014
AbstractWe introduce a holomorphic sheafℰ${\mathcal{E}}$on a Sasakian manifoldSand study two new notions of stability forℰ${\mathcal{E}}$along the Sasaki–Ricci flow related to the ‘jumping up’ of the number of global holomorphic sections ofℰ${\mathcal{E}}$at infinity.
openaire   +2 more sources