Results 101 to 110 of about 7,224,432 (309)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A New Deformation Enhancement Method Based on Multitemporal InSAR for Landslide Surface Stability Assessment

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The complex terrain and abundant ravines in the western mountainous areas of Beijing have led to dramatic changes in the geological environment. Monitoring and assessing the stability of landslide surfaces is of great significance for disaster prevention
Youfeng Liu, Honglei Yang, Runcheng Jiao, Zeping Wang, Liuyu Wang, Wei Zeng, Jianfeng Han   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Static Stability Analysis Method for Passively Stabilized Sounding Rockets

Aerospace
Sounding rockets constitute a class of rocket with a generally simple layout, being composed of a cylindrical center-body, a nosecone, a number of fins placed symmetrically around the longitudinal axis (usually three or four), and possibly a boat-tail ...
Riccardo Cadamuro, Maria Teresa Cazzola, Nicolò Lontani, Carlo E. D. Riboldi   +3 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Assessment of the Influence of Formation Conditions of Embankments and Spoil Heaps on Their Stability When Dumped on Clay-Salt Slurries

Eng
The formation of geotechnical structures on foundations composed of low-strength soils is associated with a number of risks and difficulties. Soils such as clay-salt slurries are characterized by low bearing capacity and a tendency to deform under load ...
Maxim Karasev, Tatsiana Astapenka
doaj   +1 more source

Incentives and Stability of International Climate Coalitions: An Integrated Assessment [PDF]

This paper analyses the incentives to participate in and the stability of international climate coalitions. Using the integrated assessment model WITCH, the analysis of coalitions’ profitability and stability is performed under alternative assumptions ...
Carlo Carraro, Valentina Bosetti, Enrica De Cian, Massimo Tavoni, Emanuele Massetti   +4 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Radiographic assessment of medial elbow stability

Journal of Shoulder and Elbow Surgery
Diagnosing simple valgus instability of the elbow currently involves time and cost-intensive imaging modalities such as MRI or MRA. Previous studies have demonstrated that stress radiography represents an alternative diagnostic tool for such conditions. The aim of this study was to investigate if standardized valgus stress radiography can identify soft-
Maximilian Gressl, Flamur Zendeli, Benjamin Fritz, Karl Wieser, Paul Borbas   +4 more
openaire   +2 more sources