Results 81 to 90 of about 7,224,432 (309)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Applied and Environmental MicrobiologyKlebsiella pneumoniae (K. pneumoniae) is recognized as a significant opportunistic pathogen capable of infecting both humans and animals. The emergence of multidrug-resistant strains presents a severe challenge to current antimicrobial therapies ...
Sixiang Xu +12 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
GeosciencesVolcanic caves, commonly referred to as lava tubes, are typically shallow subsurface cavities formed by the cooling of a generally basaltic lava flow under a roof or crust that cools faster and acts as a thermal insulator.
Abdelmadjid Benrabah +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Remote SensingThe Polarization and Directionality of the Earth’s Reflectances (POLDER)-3/GRASP (Generalized Retrieval of Aerosol and Surface Properties) aerosol products have been widely used in studies on radiative balance and climate change.
Xiaoyu Ma +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Physics-Inspired Deep Learning for Stability and Vibration Prediction in CNC Machining Systems
IEEE AccessAccurate prediction of machining vibrations is essential for ensuring process stability, surface quality, and intelligent monitoring in CNC manufacturing systems.
Aslain Brisco Ngnassi Djami +3 more
doaj +1 more source
ASSESSING THE STABILITY OF ESCIN
European Journal of Higher Education and Academic AdvancementDrug quality and stability are intricately linked, with temperature, light, and humidity playing crucial roles in their preservation. It is imperative for pharmacy experts to ascertain the shelf life of drugs by studying various factors such as extraction, storage, transportation, and more to establish ideal storage conditions and expiration dates ...
openaire +1 more source
Stiffness and strength of shear diaphragms used for stability bracing of slender beams [PDF]
, 2014 Structural Stability Research Council Annual Stability Conference 2014, SSRC 2014; Toronto, ON; Canada; 25 March 2014 through 28 March 2014Light gage metal decking is often used in structures as concrete deck formwork, roof cladding or siding.
Vardaroğlu, Mustafa +2 more
core +1 more source