Results 71 to 80 of about 7,224,432 (309)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Analytic solution of simplified Cardan's shaft model

Applied and Computational Mechanics, 2014
Torsional oscillations and stability assessment of the homokinetic Cardan shaft with a small misalignment angle is described in this paper. The simplified mathematical model of this system leads to the linearized equation of the Mathieu's type.
Zajíček M., Dupal J.
doaj  

Stability Assessment of an Underground Powerhouse Cavern Under Pseudo-Static and Dynamic Earthquake Loading

Applied Sciences
This study examines the seismic stability of an underground powerhouse cavern located in the Lesser Himalayan region of Nepal. Both static and seismic loading conditions are analyzed using the finite element method (FEM) and the distinct element method ...
Sailesh Adhikari, Krishna Kanta Panthi
doaj   +1 more source

Assessment of Collaborative Networks Structural Stability [PDF]

, 2007
Subject of this contribution is to develop a framework for assessment of collaborative networks (CN) structural stability on the stage of the CN design. CN design is a critical source of competitive advantage given that as much as 80% of total product cost may be fixed by these decisions. The importance of the stable CN structuring is evident.
Vera Tolkacheva, Dmitry A. Ivanov 0001, Alexander V. Arkhipov   +2 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A deep learning-based method for predicting ship dynamic stability in real-sea conditions

Zhongguo Jianchuan Yanjiu
ObjectiveTo address the limitations of the IMO second-generation intact stability assessment method—especially its inability to capture the spatiotemporal variability of real ocean environments and its limited accuracy in evaluating ship instability risk—
Xinmiao CUI, Xinyuan ZHANG, Jie ZHANG, Limin HUANG   +3 more
doaj   +1 more source

Arctic Ocean Acidification 2013: An Overview

, 2014
Report presenting a summary of the first comprehensive assessment of Arctic Ocean acidification (AOA) conducted by the Arctic Monitoring and Assessment Programme (AMAP).
Arctic Monitoring and Assessment Programme
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Anti-capsizing stability checking for jack-up platforms based on ALE approach

Zhongguo Jianchuan Yanjiu
Objective This study addresses the challenges associated with high computational cost in nonlinear analysis and the insufficient accuracy of code-based methods for the anti-capsizing stability check of jack-up platforms with independent spud legs.
Xiaolei LIU, Mo WANG, Zhinan ZHOU
doaj   +1 more source