Results 81 to 90 of about 310,213 (265)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
L1(R)-Nonlinear Stability of Nonlocalized Modulated Periodic Reaction-Diffusion Waves
Advances in Mathematical Physics, 2017 Assuming spectral stability conditions of periodic reaction-diffusion waves u¯(x), we consider L1(R)-nonlinear stability of modulated periodic reaction-diffusion waves, that is, modulational stability, under localized small initial perturbations with ...
Soyeun Jung
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Identification hyperbolic problems with the Neumann boundary condition
Қарағанды университетінің хабаршысы. Математика сериясы, 2018 In the present study, an identification problem with the Neumann boundary condition for a one-dimensional hyperbolic equation is investigated. Stability estimates for the solution of the identification problem are established. Furthermore, a first order
A. Ashyralyev, F. Emharab
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Computer Assisted Methods in Engineering and Science, 2023 In order to avoid a fully nonlinear prebuckling analysis by the finite element method for the mere purpose of btaining the stability limit in the form of a bifurcation or a snap-through point, this limit may be estimated by means of the solution of a ...
Peter Helnwein +2 more
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Stability of nonlinear waves: Pointwise estimates
Discrete and Continuous Dynamical Systems - S, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source