Results 41 to 50 of about 25,813 (128)

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Coping Practices of Small‐ and Medium‐Sized Enterprises Facing Power Asymmetry in Digital Platform Business

Strategic Change, EarlyView.
ABSTRACT Digital platform (DP) enterprises have risen to the top of the global economy by inverting traditional business models. They earn money through matchmaking, transaction facilitation, and efficient orchestration of other stakeholders' resources.
Lukas R. G. Fitz, Jochen Scheeg
wiley   +1 more source

Unveiling New Perspectives on the Hirota–Maccari System With Multiplicative White Noise

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In this study, we delve into the stochastic Hirota–Maccari system, which is subjected to multiplicative noise according to the Itô sense. The stochastic Hirota–Maccari system is significant for its ability to accurately model how stochastic affects nonlinear wave propagation, providing valuable insights into complex systems like fluid dynamics
Mohamed E. M. Alngar, Khaled A. Gepreel, Reham M. A. Shohib, Yakup Yildirim   +3 more
wiley   +1 more source

From Stability to Chaos: A Complete Classification of the Damped Klein‐Gordon Dynamics

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT We investigate the transition between stability and chaos in the damped Klein‐Gordon equation, a fundamental model for wave propagation and energy dissipation. Using semigroup methods and spectral criteria, we derive explicit thresholds that determine when the system exhibits asymptotic stability and when it displays strong chaotic dynamics ...
Carlos Lizama, Marina Murillo‐Arcila, Julio Puerta‐Fernández   +2 more
wiley   +1 more source

Effect of Designed 3D Reinforcement in Mitigating Machining Damage on CFRP Plates

Polymer Composites, EarlyView.
Effect of Edge Tufting on Surface Quality, Damage, and Mechanical Performance in CFRP Machining: A Comparative Topographical and Structural Analysis. ABSTRACT Composite materials made of carbon fiber‐reinforced epoxy (CFRP) are widely used in aerospace fields due to their high strength‐to‐weight ratio. However, due to low out‐of‐plane resistance, these
Thiago Luiz Lara Oliveira, Daniel Brighenti Bortoluzzi, Antônio Carlos Ancelotti Jr   +2 more
wiley   +1 more source

Quantum Iterative Methods for Solving Differential Equations with Application to Computational Fluid Dynamics

Advanced Quantum Technologies, EarlyView.
Quantum algorithms for differential equations are developed with applications in computational fluid dynamics. The methods follow an iterative simulation framework, implementing Jacobi and Gauss–Seidel schemes on quantum registers through linear combinations of unitaries.
Chelsea A. Williams, Antonio A. Gentile, Vincent E. Elfving, Daniel Berger, Oleksandr Kyriienko   +4 more
wiley   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, EarlyView.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Transforming Fragile Hydrogel Chips Into Standardized Cartridges via Contact Line Pinning for Robust Microfluidics

Small, EarlyView.
Hydrogel‐based microfluidic chips revolutionize drug delivery, tissue engineering, and biosensing, yet face challenges due to fragility and connection difficulty. This study introduces a novel cartridge design that enhances usability through a hydrogel–plastic hybrid design and a contactless connection method.
Sin‐Yung Siu, Chiu‐Wing Chan, Yisu Wang, Langcheng Feng, Yichen Su, Yin Chen, Christopher K C LAI, Pingan Zhu, Kangning Ren   +8 more
wiley   +1 more source

Physics‐Driven Deep Neural Networks for Solving the Optimal Transport Problem Associated With the Monge–Ampère Equation

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Monge–Ampère equations (MAEs) are fully nonlinear second‐order partial differential equations (PDEs), which are closely related to various fields including optimal transport (OT) theory, geometrical optics and affine geometry. Despite their significance, MAEs are extremely challenging to solve.
Xinghua Pan, Zexin Feng, Kang Yang
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source