Results 61 to 70 of about 25,964 (155)

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease

MedComm, Volume 7, Issue 5, May 2026.
XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang, Wei Wang, Li Zhang, Jiwei Huang, Lei Huang, Huibo Wu, Yuyin Qi, Lili Li, Liren Tan, Min Zhang, Jianheng Zhu, Xiang Peng, Kanghua Zhong, Ming Zou, Xi Yang, Qiuhua Wang, Changjun Nie, Chaorui Tang, Ning Tang, Lanlan Geng, Hanhan Chen, James E. Vince, Hirokazu Kanegane, Xiaodong Zhao, Huifang Xian, Wenhao Zhou, Min Zhi, Yuxia Zhang, Zhanghua Chen   +28 more
wiley   +1 more source

The Stability of Oral Language Profiles of Children in the Early Years of School: A Longitudinal Comparison of Multidimensional and Cut‐Point Approaches to Classification

International Journal of Language &Communication Disorders, Volume 61, Issue 3, May/June 2026.
ABSTRACT Background A cut‐point approach to classifying children's language abilities uses a specific threshold to determine whether an individual falls into a particular group, such as children with ‘typically developing language’ or ‘language difficulties.’ This method has been frequently used in longitudinal research to track language during the ...
Anna Louise Taylor, Suze Leitão, Sharon Smart, Robyn Wheldall, Mary Claessen, Elien Vanluydt, Mark E. Boyes   +6 more
wiley   +1 more source

Rates and Predictors of Persistent LUTS Medication Use After Laser Enucleation of the Prostate

LUTS: Lower Urinary Tract Symptoms, Volume 18, Issue 3, May 2026.
ABSTRACT Objectives To assess rates of medication use for lower urinary tract symptoms (LUTS) over time following laser enucleation of the prostate (LEP) and to identify preoperative predictors of persistent use. Methods We retrospectively analyzed 864 LEP patients from an institutional tertiary‐care database (11/2017–05/2023) with available 24‐month ...
Maximilian Filzmayer, Miriam I. Traumann, Clara Humke, Matthias J. Müller, Philipp C. Mandel, Luis A. Kluth, Andreas Becker, Felix K.‐H. Chun, Marina Kosiba   +8 more
wiley   +1 more source

Robust Inverse Material Design With Physical Guarantees Using the Voigt‐Reuss Net

International Journal for Numerical Methods in Engineering, Volume 127, Issue 7, 15 April 2026.
ABSTRACT We apply the Voigt‐Reuss net, a spectrally normalized neural surrogate introduced in [38], for forward and inverse mechanical homogenization with a key guarantee that all predicted effective stiffness tensors satisfy Voigt‐Reuss bounds in the Löwner sense during training, inference, and gradient‐driven optimization.
Sanath Keshav, Felix Fritzen
wiley   +1 more source

Effect of Designed 3D Reinforcement in Mitigating Machining Damage on CFRP Plates

Polymer Composites, Volume 47, Issue 7, Page 6773-6784, 10 April 2026.
Effect of Edge Tufting on Surface Quality, Damage, and Mechanical Performance in CFRP Machining: A Comparative Topographical and Structural Analysis. ABSTRACT Composite materials made of carbon fiber‐reinforced epoxy (CFRP) are widely used in aerospace fields due to their high strength‐to‐weight ratio. However, due to low out‐of‐plane resistance, these
Thiago Luiz Lara Oliveira, Daniel Brighenti Bortoluzzi, Antônio Carlos Ancelotti Jr   +2 more
wiley   +1 more source

Roadmap to Precision 3D Printing of Cellulose: Rheology‐Guided Formulation, Fidelity Assessment, and Application Horizons

Advanced Materials Technologies, Volume 11, Issue 8, 17 April 2026.
This critical review presents a comprehensive roadmap for the precision 3D printing of cellulose. Quantitative correlations link ink formulation and rheological properties to print fidelity and final material performance. This framework guides the development of advanced functional materials, from biomedical scaffolds to electromagnetic shielding ...
Majed Amini, Hadi Hosseini, Seyyed Alireza Hashemi, Mohammad Arjmand   +3 more
wiley   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Red Blood Cell Membrane Mechanics Using Discrete Exterior Calculus (DEC) and Optimization

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 4, April 2026.
We present a novel DEC approach for calculating RBC shapes applicable to other cell types and membrane problems. We derive an energy minimization equation that can be solved semi‐implicitly, and a Lie derivative method to control node spacing. This novel work should aid computational modeling in many biological situations.
Keith C. Afas, Daniel Goldman
wiley   +1 more source

PVRI‐GoDeep—A Global Meta‐Registry at the Crossroads of Heart and Lung

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
PVRI GoDeep is a global meta‐registry that harmonizes high‐quality patient‐level data from pulmonary hypertension registries worldwide. With over 45,000 enrolees already included, it enables robust phenotyping, international comparisons, and clinically relevant research across all PH subgroups beyond the scope of single‐center or national datasets ...
Meike T. Fuenderich, Athiththan Yogeswaran, Patrick Janetzko, Khodr Tello, Werner Seeger, Raphael W. Majeed, Jochen Wilhelm, GoDeep Consortium, Mauro Acquaro, Imad Al Ghouleh, James Anderson, Jeffrey S. Annis, Anastasia Anthi, Alexandra Arvanitaki, Aparna Balasubramanian, Felix Ballmann, Harm Jan Bogaard, Evan Brittain, Hugh Buzacott, Hector R. Cajigas, John Cannon, Stephen Y. Chan, Victoria Damonte, Effrosyni Dima, Philipp Douschan, Nathan Dwyer, Diego Echazarreta, Christina A. Eichstaedt, Jean Elwing, Kai Förster, Robert Frantz, Marlize Frauendorf, Stefano Ghio, Hossein‐Ardeschir Ghofrani, George Giannakoulas, Friedrich Grimminger, Ekkehard Grünig, Lars Harbaum, Paul M. Hassoun, Melanie Heberling, Anne Hilgendorff, Luke Howard, Arun Jose, Ernesto Junaeda, David G. Kiely, Ingrid King, Hans Klose, Ziad Konswa, Gabor Kovacs, Philipp Krieb, Keiichiro Kuronuma, Edmund M. Lau, Melanie Lavender, Allan Lawrie, Mona Lichtblau, Kurt Marquardt, Hiromi Matsubara, Farhan Mubashir, Horst Olschewski, Mauricio Orozco‐Levi, Karen Osborn, Joanna Pepke‐Zaba, Alba Ramirez‐Sarmiento, Stephan Rosenkranz, Hani Sabbour, Sandeep Sahay, Khaled Saleh, Laura Scelsi, Yuriy Sirenko, Siva Sivakumaran, Andrew J. Sweatt, Thenappan Thenappan, Ioan Tilea, Olena Torbas, Silvia Ulrich, Andrea Varga, Helen M. Whitford, Christoph B. Wiedenroth, Martin R. Wilkins, Paul G. Williams, Shaun Yo, Roham T. Zamanian, Zhenguo Zhai, Zhu Zhang   +83 more
wiley   +1 more source

Benchmark Response Values for Error‐Corrected Sequencing Mutagenicity Assessment Technologies

Environmental and Molecular Mutagenesis, Volume 67, Issue 4, April 2026.
ABSTRACT The Benchmark Dose (BMD) approach is commonly used to determine Point‐of‐Departure (PoD) values for risk assessment and regulatory decision‐making; however, choosing a suitable Benchmark Response (BMR) for continuous endpoints is a challenge.
Saron Mulugeta, Francesco Marchetti, Guangchao Chen, Connie Chen, Raechel Puglisi, Paul A. White   +5 more
wiley   +1 more source