Results 41 to 50 of about 181,769,327 (177)

Feedback Linearisation with State Constraints

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Feedback Linearisation (FBL) is a widely used technique that applies feedback laws to transform input‐affine nonlinear control systems into linear control systems, allowing for the use of linear controller design methods such as pole placement.
Songlin Jin, Yuanbo Nie, Morgan Jones
wiley   +1 more source

DualSS: A Dual‐Diffusion Synthetic Sampling Framework for Screening Fatty Liver Severity With Class‐Imbalanced Tongue Images

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Fatty liver disease (FLD) is a prevalent chronic condition that can progress to clinically significant liver injury if left untreated. Given its high prevalence, FLD poses a substantial public health burden. Traditional Chinese medicine suggests that the appearance of tongue reflects hepatic and metabolic status, enabling artificial ...
Tao Chen, Jie Gao, Yong Xu, Weihong Qiu, Kunhong Liu, Yijie Wu, Weimin Ye   +6 more
wiley   +1 more source

Non-linear coupled CNN models for multiscale image analysis [PDF]

, 2006
A CNN model of partial differential equations (PDEs) for image multiscale analysis is proposed. The model is based on a polynomial representation of the diffusivity function and defines a paradigm of polynomial CNNs,for approximating a large class of ...
Corinto, Fernando, Biey, Mario, Gilli, Marco   +2 more
core   +1 more source

Treatment Patterns and Pathways of Systemic Drug Therapy in Patients With Plaque, Erythrodermic, and Generalized Pustular Psoriasis: A Retrospective Cohort Study in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Systemic psoriasis treatment options have rapidly expanded in Japan, including the approval of tyrosine kinase 2 and interleukin‐36 receptor inhibitors in 2022. However, contemporary real‐world treatment patterns across plaque, erythrodermic, and generalized pustular psoriasis remain incompletely characterized.
Yayoi Tada, Yoshiko Maeda, Miyuki Hasegawa, Motonobu Sakaguchi, Takamasa Hashimoto, Teruko Narusawa, Nobuyoshi Takabayashi, Tomoko Takahashi, Taisuke Kondo, Shingo Kuroda   +9 more
wiley   +1 more source

Systemic Treatment of Psoriasis: Current Evidence on Efficacy and Safety

The Journal of Dermatology, EarlyView.
ABSTRACT Systemic treatments for moderate‐to‐severe plaque psoriasis have been advanced from broad immunosuppressants up to agents more selectively targeting cytokines, cytokine receptors, or intracellular signaling. The current systemic treatments mainly consist of conventional systemic agents, biologics targeting tumor necrosis factor (TNF)‐α ...
Teppei Hagino, Naoko Kanda
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

A comparative study of a system of Lotka-Voltera type of PDEs through perturbation methods [PDF]

, 2013
In this paper the Adomian Decomposition Method (ADM) is employed in order to solve linear and nonlinear functional equations and the results are then compared with those produced by Homotopy Perturbation Method (HPM) through a system of Lotka Voltera ...
H. A. Waha, T. Khan, et al., M. Shakil
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Stability for nonlinear diffusive PDEs [PDF]

, 2018
This thesis focuses on well-posedness and stability estimates (i.e. continuous dependence with respect to the nonlinearities) for a family of cross-diffusion systems that includes several models used to describe cell diffusion in Mathematical Biology for
Luca Cesare Biagio Alasio, Alasio, Luca Cesare Biagio   +1 more
core   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source