Results 91 to 100 of about 861,879 (285)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Scientific World Journal, 2014 Differential inequalities, comparison results, and sufficient conditions on initial time difference stability, boundedness, and Lagrange stability for fractional differential systems have been evaluated.
Muhammed Çiçek +2 more
doaj +1 more source
Viscous compressible flow about blunt bodies using a numerically generated orthogonal coordinate system [PDF]
A numerical solution to the Navier-Stokes equations was obtained for blunt axisymmetric entry bodies of arbitrary shape in supersonic flow. These equations are solved on a finite difference mesh obtained from a simple numerical technique which generates ...
Graves, R. A., Jr., Hamilton, H. H., II
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On the stability of linear fractional difference systems [PDF]
, 2012 A fractional linear system is defined by differential or difference equations of non-integer order. A well-known result about the stability of fractional differential systems will be extended to discrete-time systems defined by fractional difference ...
Pereira, Ricardo, Vettori, Paolo
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Stability theorems of stochastic difference equations
Journal of Mathematical Analysis and Applications, 1990 Let \(\{A_ n\); \(n\geq 0\}\) be an independent sequence of \(d\times d\) real-valued matrices and f(n,x) be an \({\mathbb{R}}^ d\) valued mapping defined on \({\mathbb{N}}\times {\mathbb{R}}^ d\). The author investigates various definitions of the stability of the solutions of the equation \[ x_{n+1}=A_ nx_ n+f(n,x_ n),\quad x_ 0\in {\mathbb{R}}^ d. \]
openaire +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Analytical method for determining the stability of linear retarded systems with two delays [PDF]
The stability is considered of the solution differential-difference equations of the retarded type with constant coefficients and two constant time delays.
Barker, L. K., Whitesides, J. L.
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