Results 141 to 150 of about 379,663 (282)

Amendments to the constitution of the RF and the stability of the basic law

, 2021
A.N. Alekseev
openalex   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Study protocol for a randomized controlled trial to evaluate the effectiveness of an artificial intelligence-based health education accurately linking system based on traditional Chinese medicine body constitution in patients with chronic disease multimorbidity. [PDF]

Front Public Health
Liu Q, Yang Y, Hu Y, Yang X, Liu S, Bao R, Wu Y.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Veto Power and Wealth: Analysis of the Development of the Swiss Old Age Security [PDF]

Switzerland was one of the last OECD-countries to introduce a program for old age security – the AHV. For many decades, expenditures both in absolute terms and as a portion of GDP remained low in OECD comparison.
Zenker, Christina G.
core   +1 more source

The correlation between traditional Chinese medicine constitution and prediabetes: a systematic review and meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Chen L, Wang Y, Xie X, Zhou Z, Xie L, Cai J, Li H, Zhang X, Ke Y, Li Q, Wu Z, Zhao X, Wang W.   +12 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Traditional Chinese medicine constitution and cardiometabolic multimorbidity: a nationwide cross-sectional study in older adults. [PDF]

Front Public Health
Chen R, Li HQ, Xia J, He FY, Zhang Y, Wang Z, Zhang HY, Yang YM, Bai MH, Ni C.   +9 more
europepmc   +1 more source

CONSTITUTIONAL REFORM: A THEORY OF STABILITY OR INSTABILITY OF THE DEMOCRATIC CONSTITUTIONAL PROJECT?

, 2015
This article aims to analyze to what extent the constitutional reforms imply stability or instability of the constitution. Under constitutionalism, the limitations imposed on the State are aimed at the maintenance and preservation of the democratic constitutional project built by political will manifested by the sovereign constituent assembly ...
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source