Results 151 to 160 of about 21,178 (307)

The role of the family constitution in a family business.

The changing environment of family businesses and the emerging conflicts over the distribution of responsibilities and inheritance processes, as well as different approaches of family members to business management, highlight the importance of the family
Dargis, Nojus,
core  

Education System of Pakistan: Social Functions and Challenges

, 2020
Education is a key to political stability and socio-economic development of a nation. Unfortunately, there are diverse systems of education providing different types of education leading to stratified education system.
Shoukat Ali; University of the Punjab, Lahore., Zubaida Zafar; University of the Punjab, Lahore.   +1 more
core  

Self-Deception and Agential Authority . Constitutivist Account

Humana.Mente: Journal of Philosophical Studies, 2012
This paper takes a constitutivist approach to self-deception, and argues that this phenomenon should be evaluated under several dimensions of rationality.
Carla Bagnoli
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Preparation-Dependent Microstructure and Hydrogen Storage in High-Entropy Alloys. [PDF]

Molecules
Chen C, Hou Q, Zhou Y, Ding Z.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Machine Learning and Traditional Chinese Medicine Constitution-Based Prediction Model for Mild Cognitive Impairment in Community-Dwelling Older Adults. [PDF]

Neuropsychiatr Dis Treat
Xu Q, Huang Z, Su W, Cai A, Chen Z, Zhou W, Li J, Chen X.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

New Constitution, New Europe: What About (Fiscal) Federalism? [PDF]

More than fifty years after the Schuman Declaration, Europe is still far from a real Political Union. In fact, Europe faces an important imbalance between the two sides of the integration process, appearing as an important actor in the international ...
Rui Henrique Alves
core  

Bulk Versus Surface Regulation of Cyclic Superelasticity in LPBF-Fabricated NiTi Alloy. [PDF]

Materials (Basel)
Yang Y, Wei T, Su C, Wan J, Nie X, Yang J.   +5 more
europepmc   +1 more source