Results 171 to 180 of about 379,663 (282)

Effects of <i>Bacopa monnieri</i> herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in relation to constitution (<i>Prakriti</i>) in healthy adults: clinical trial protocol. [PDF]

Front Med (Lausanne)
Pradeep HLNR, Perera PK, Waratenne PR, Samaranayake N, Dissanayake WDN.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A Phase 1, Randomized, Open-Label Study to Assess the Bioequivalence of Trofinetide as a Ready-to-Use Oral Solution and Constituted Powder for Oral Solution in Healthy Adults. [PDF]

Adv Ther
Darwish M, Yamamoto A, Adegbenle Y, Tejwani R, Chen Y, Nunez-Disla R, Youakim JM, Pathak S.   +7 more
europepmc   +1 more source

Constitutional Stability and the Role of Countermajoritarian Rules (or How We Learned to Stop Worrying and Love our Antidemocratic Constitution)

Daniel B. Rodriguez, Barry R. Weingast
openalex   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Cardio-Cerebral Protective Effect of Moxibustion on Phlegm-Dampness Type Hypertension: Protocol for a Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Cheng L, Bai N, Zheng L, Cao L, Wu H, Wang R, Zhao C, Shen Y, Zhao H, Li G, Yang B, Yang Q, Xing Y, Cao J, Wang Y, Xu L, Yan J, Cao J, Guo Y.   +18 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A scale for assessing the health of children aged 3-6 years in China: development and validation of the TCM constitution scale (3-6 years). [PDF]

Front Public Health
Li W, Dong S, Li Z, Chen S, Cai Y, Bai MH, Chen JX, Wang J.   +7 more
europepmc   +1 more source

Parliamentary system and the stability of Croatian constitution: Will the presidential elections be followed by changes in government structure ?

, 2010
Branko Smerdel
openalex   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source