Results 171 to 180 of about 21,178 (307)

The Constitution of Brazil ::a contextual analysis /

, 2019
"This book aims to offer an original and comprehensive analysis of Brazilian constitutional law and to show how the 1988 Constitution has been a cornerstone in Brazil's institutional stability.
Silva, Virgílio Afonso da,
core  

Research on intelligent identification of Traditional Chinese Medicine constitutions based on multi-model fusion. [PDF]

J Tradit Chin Med
Yao Y, Xiaohong C.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Taxation and political stability

The present study is, in particular, an attempt to test the relationship between tax level and political stability by using some economic control variables and to see the relationship among government effectiveness, corruption, and GDP.
Estrada, Fernando, Mutascu, Mihai, Tiwari, Aviral   +2 more
core  

Effect of Y₂O₃ Content on the Microstructure and Thermal Shock Resistance of Al₂O₃-Y₂O₃ Composite Coatings. [PDF]

Materials (Basel)
Hu Z, Feng L, Zhao Y, Wei Z, Liu B, Ma C, Cheng B.   +6 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Meta-analysis of Traditional Chinese Medicine constitution distribution in people with functional constipation. [PDF]

J Tradit Chin Med
Xuehui W, Yuxin S, Yoann B, Xun LI, Ruotong Z, Youyou Z, Zhenmei S, Yanli Z, Hongbo DU, Jianyun W, Yinqing LI, Zhaolan L, Jianping L.   +12 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Development and Validation of a Traditional Chinese Medicine Constitution-Based Risk Score for Advanced Colorectal Neoplasia in Asymptomatic Chinese Adults. [PDF]

Cancer Manag Res
Huang C, Hou Y, Liu QH, Kang Q, Fan YJ, Zhu LQ, Sun L, Men RC, Li XY, Gu YL, Ni Q, Wang H, He Y.   +12 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source