Results 31 to 40 of about 160,173 (217)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
On calculation of the stability radius for a minimum spanning tree
Журнал Белорусского государственного университета: Математика, информатика, 2017 We consider a minimum spanning tree problem in the situation where weights of edges are exposed to independent perturbations. We study a quantitative characteristic of stability for a given optimal solutions of the problem.
Yauheni D. Zhyvitsa, Kiril G. Kuzmin
doaj
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
On the stability of convex symmetric polytopes of matrices
Electronic Journal of Differential Equations, 2000 In this warticle we investigate the stability properties of a convex symmetric time-varying second-order matrix's polytope depending on a real positive parameter $r$.
Gilner de la Hera Martinez +2 more
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Les relations sociales, frein ou moteur de la durabilité
Développement Durable et Territoires, 2013 Development paths may include contradictions between the different dimensions of sustainability. This article shows the usefulness of the notion of radius of trust in order to evaluate the contribution of social relationships to sustainability.
Jean-Marc Callois
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
On the Stability of a class of Polytopes of third order square matrices and stability radius
Revista de Matemática: Teoría y Aplicaciones, 2011 In this work we investigate the stability properties of a convex symmetric timeinvariant third order matrix's polytope depending on a real positive parameter $r$.
Efrén Vázquez Silva
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FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source