Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source
Matrifibrocytes Redefine Cardiac Fibrosis: From Terminal Differentiation to Translational Modulation. [PDF]
J Cell Mol MedZhang Z, Zhu H.
europepmc +1 more source
A Ku-Band 13 W GaN HEMT Power Amplifier MMIC with a Coupled-Line Interstage Stabilization Technique for Radar Sensor Systems. [PDF]
Sensors (Basel)Kim J.
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The fibrosis-plasticity axis (FPA) and ionic resilience: a systems framework for understanding adverse drug reactions in ageing populations. [PDF]
Front PharmacolCarballo A.
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Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation. [PDF]
NPJ Syst Biol ApplMarkovic S +3 more
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Behavioral Dentistry in the Digital Age: A Review of Biofeedback Occlusal Splint Therapy. [PDF]
CureusChipper A +5 more
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Existence, Stability, and Control of Glucose-Insulin Dynamics via Caputo-Fabrizio Fractal-Fractional Operators. [PDF]
MethodsXSaber S, Alahmari AA.
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