Results 171 to 180 of about 69,372 (313)

Formulation and Evaluation of Indomethacin Nanosuspensions Stabilized by Poly(2-oxazine) and Poly(2-oxazoline)-Based Polymers for Solubility Enhancement. [PDF]

Pharm Res
Espo E, Potdar D, Baas K, Keßler L, Yang M, Bērziņš K, Kemell M, Kiiskinen T, Heinonen A, Kehrein J, Boyd BJ, Karttunen AP, Peltonen L, Luxenhofer R, Bunker A, Viitala T.   +15 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Stabilizers used in nanocrystal based drug delivery systems

, 2014
Nanocrystals have emerged as a viable tool to enhance oral bioavailability of poorly water soluble drugs. They also enable parenteral administration of these drugs as nanosuspensions.
Jain, Hemant, Prajapat, Hitesh, Akotiya, Priya, Punj, Deeksha, Bansal, Arvind Kumar, Shete, Ganesh   +5 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

ECONOMIC AND SOCIAL STABILIZERS UNDER ECONOMIC GROWTH PERIOD IN RUSSIA

, 2011
The role of socio-economic stabilization mechanisms under the economic growth is considered. Various approaches to the classification of automatic stabilizers are discussed. Some tax and social stabilizers under the economic growth period of 2000–2008 in
Tatiana A. Grosheva
core  

Stabilization strategies and advancements in lyophilization to preserve integrity and efficacy of next-generation biologicals. [PDF]

Int J Pharm X
Maharjan R, Shin CY, Lee SK, Ha ES, Park H, Kim JS, Kim KH, Kim NA, Kim MS, Jeong SH.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Protein-Protein Interaction Stabilizers from MD Simulation-Derived Pharmacophores. [PDF]

J Chem Inf Model
Ibrahim M, Zacharias M.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence. [PDF]

Neuropsychopharmacol Rep
Bereda G.
europepmc   +1 more source