Results 131 to 140 of about 129,759 (303)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Source Analysis of Benzene Homologues Based on Stable Carbon Isotopes

Zhipu Xuebao
Benzene homologues, including compounds such as benzene, toluene, and xylene, have become key pollutants of concern in food, drug, and environmental safety cases due to their significant carcinogenicity and ecotoxicity.
Han-yang ZHENG, Zhuo-tong CAI, Zhao-wei JIE, Han-yu ZHANG, Wei WANG, Can HU, Ya-jun LI, Hong-ling GUO, Zhan-fang LIU, Jun ZHU, Hong-cheng MEI   +10 more
doaj   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Nanozymes for Energy and Environmental Sustainability

Advanced Science, EarlyView.
At present, the widely used nanozymes are oxidoreductase and hydrolase, which have proved to have great application prospects in energy and environment. ABSTRACT Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability.
Xiaoqi Li, Jinxing Chen, Shaojun Dong
wiley   +1 more source

Surface Graphitized Mesoporous Carbon Surpasses the Conductivity–Porosity Trade‐Off

Advanced Science, EarlyView.
Electrochemical cathodic polarization in molten CaCl2‐NaCl converts mesoporous carbon (MC) into surface‐graphitized mesoporous graphite, simultaneously increasing surface area (397–867 m2/g) and electrical conductivity (26–450 S/cm) without mass loss.
Juntian Fan, Yating Yuan, Tao Wang, Huimin Luo, Fan Wang, Qingju Wang, Shannon M. Mahurin, Bishnu P. Thapaliya, Lilin He, Jue Liu, Nikolaos Samartzis, Zhenzhen Yang, Sheng Dai   +12 more
wiley   +1 more source

A Generalized Approach for Distal C–H Arylation of Organic Building Blocks: Unveiling the Role of Counter Anion

Advanced Science, EarlyView.
We report a general strategy for meta‐selective C–H arylation using aryl iodides and a Pd(II)/Pd(IV) catalytic system guided by a removable directing group. DFT and experimental studies reveal that counter anion tuning (acetate to trifluoroacetate) significantly enhances selectivity.
Jagrit Grover, Gaurav Prakash, Astam Mandal, Devika Ghosh, Siddhartha Maiti, Claire Empel, Debabrata Maiti   +6 more
wiley   +1 more source

Beyond Sabatier: Multiplicate Spillover Phenomena for Manipulating Catalytic Dynamics in Various Electrocatalysis

Advanced Science, EarlyView.
Various spillover‐mediated electrocatalytic reactions, such as hydrogen and oxygen evolution, carbon dioxide and nitrogen reduction, and methanol oxidization reactions, are systematically summarized. Abstract Spillover phenomenon, which is characterized by the dynamic migration of active species across catalyst surfaces, provides a promising avenue to ...
Di Wang, Ziyou Dong, Qianqian Yao, Shixue Dou, Jun Mei, Ziqi Sun   +5 more
wiley   +1 more source

Recent benthic foraminifera from the Tagus Prodelta and Estuary, Portugal: microhabitats, assemblage composition and stable isotopes [PDF]

, 2006
Abrantes, Fatima G., Bartels-Jónsdóttir, Helga Bára, Knudsen, Karen Luise, Lebreiro, Susana M., Schönfeld, Joachim   +4 more
core   +1 more source

Quantifying carbon allocation to mycorrhizal fungi by temperate forest tree species across a nitrogen availability gradient [PDF]

, 2013
Terrestrial ecosystems make up the largest carbon pool with a major portion of that being forests. With carbon being a major concern due to global climate change, being able to make accurate models is increasingly important. Studies have shown that trees
Tumber-Davila, Shersingh Joseph
core   +1 more source