Results 131 to 140 of about 3,681,214 (292)

Stable carbon isotope evolution of formaldehyde on early Mars

Scientific Reports
Organic matter in the Martian sediments may provide a key to understanding the prebiotic chemistry and habitability of early Mars. The Curiosity rover has measured highly variable and 13C-depleted carbon isotopic values in early Martian organic matter whose origin is uncertain.
Shungo Koyama, Tatsuya Yoshida, Yoshihiro Furukawa, Naoki Terada, Yuichiro Ueno, Yuki Nakamura, Arihiro Kamada, Takeshi Kuroda, Ann Carine Vandaele   +8 more
openaire   +3 more sources

Non-traditional stable isotopes

, 2017
The development of multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS) makes it possible to precisely measure non-traditional stable isotopes.
Dauphas, Nicolas, Teng, Fang Zhen, Watkins, James M.   +2 more
core  

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Understanding and Regulating C–N Coupling Pathways for Electrocatalytic Urea Synthesis From CO2 and NO3−/NO2−

Advanced Science, EarlyView.
Understanding and regulating C–N coupling is central to electrocatalytic urea synthesis from CO2 and NO3−/NO2−. This review outlines representative coupling pathways, summarizes carbon‐ and nitrogen‐side intermediate regulation strategies, and highlights in situ/operando tools for mechanistic clarification and catalyst design. ABSTRACT Electrocatalytic
Xingbao Chen, Zhuo Li, Lebin Cai, Paul Kilmartin, Bao Yu Xia, Ziyun Wang   +5 more
wiley   +1 more source

Including Stable Carbon Isotopes to Evaluate the Dynamics of Soil Carbon in the Land-Surface Model ORCHIDEE. [PDF]

J Adv Model Earth Syst, 2019
Camino-Serrano M, Tifafi M, Balesdent J, Hatté C, Peñuelas J, Cornu S, Guenet B.   +6 more
europepmc   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Linker‐Locking Strategy for the Rigidification of Flexible Metal–Organic Framework: Structural Stabilization and Controlled ESIPT for H2O/D2O Sensing

Advanced Science, EarlyView.
A linker‐locking strategy rigidifies the flexible metal–organic framework (MOF) MIL‐53‐(OH)2 via the cooperative encapsulation of ligands and structural water. This network significantly enhances the framework's aqueous stability. Crucially, rigidification suppresses enol emission to yield a single keto tautomer state with an extended lifetime ...
Amitosh Sharma, Seonghwan Lee, Seo I Park, Hak‐Won Nho, Junmo Seong, Eunseo Lee, Oh‐Hoon Kwon, Myoung Soo Lah, Jaewoong Lim   +8 more
wiley   +1 more source

Metabolism and foraging strategies of mid-latitude mesozooplankton during cyanobacterial blooms as revealed by fatty acids, amino acids, and their stable carbon isotopes. [PDF]

Ecol Evol, 2019
Eglite E, Graeve M, Dutz J, Wodarg D, Liskow I, Schulz-Bull D, Loick-Wilde N.   +6 more
europepmc   +1 more source