Results 141 to 150 of about 97,749 (304)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Applications of singularity theory to neurobiology [PDF]
The nervous system of animals contains certain specialized cells, called nerve cells or neurones, that are responsible for the transmission of information within the animal's body.
Labouriau, Isabel Salgado
core
Unstable and neutrally stable modes in barotropic and baroclinic shelf slope currents. [PDF]
, 2002 The stability of barotropic and baroclinic shelf slope currents currents is investigated. Assuming periodic small amplitude perturbation in along shelf direction the stability problem is reduced to an eigenvalue problem by discretization in the across ...
Gjevik, Bjørn
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Measurements of vertical air currents in the atmosphere [PDF]
, 1931 To summarize, the experiments with balloons, sailplanes and light airplanes conducted thus far, reveal the vertical velocities of the air to be primarily dependent on the vertical temperature distribution.
Lange, K O
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Currents, Vol.1, No.14 (Apr.11, 1983) [PDF]
, 1983 Leader in Education Heads New Graduate Program--Sex Myths Explored--A Gift of Music--Witherill to Retire--The Age of the Computer--Financial Aid Funding Remains Stable--Opening Windows on the World--Science, History on the Upswing--The Press and the ...
Caswell, Robert S.
core +1 more source
Performance Analysis of Model-Based Control for Thermoelectric Window Frames
BuildingsThe Thermoelectric Window Frame (TEWF) can be adjusted by regulating the operating current to achieve the desired indoor temperature. However, indoor and outdoor ambient disturbances are inevitable, causing indoor temperature fluctuations and preventing ...
Zhineng He +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source