Results 131 to 140 of about 97,749 (304)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A comparison of Cluster magnetic data with the Tsyganenko 2001 model. [PDF]

, 2007
As part of an investigation of the magnetic effects of external currents in the magnetosphere, we have compared two years of perigee Cluster data to the Tsyganenko 2001 (T01) field model.
Davies, J. A., Holme, R., Dunlop, M. W., Woodfield, E. E., Hapgood, M. A.   +4 more
core  

CURRENT STATE OF MICROPLASMA WELDING [PDF]

Fiabilitate şi Durabilitate
Microplasma welding (MPW) represents an advanced evolution of plasma arc welding, offering precise, low heat joining solutions for thin metallic materials, particularly below 1 mm thickness. By utilizing a stable pilot arc and a constricted plasma jet,
Paul-Adrian STRĂJERU, Corneliu RONTESCU, Ana-Maria BOGATU, Dumitru-Titi CICIC   +3 more
doaj  

High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

High Power Laser Science and Engineering
We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser ...
Michael Ehret, Jakub Cikhardt, Philip Wykeham Bradford, Iuliana-Mariana Vladisavlevici, Tomas Burian, Diego de Luis, Jose Luis Henares, Rubén Hernández Martín, Jon Imanol Apiñaniz, Roberto Lera, José Antonio Pérez-Hernández, João Jorge Santos, Giancarlo Gatti   +12 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Circulation in stratified lakes due to flood-induced turbidity currents [PDF]

The river inflow in a natural lake with important suspended sediment load during floods, can impact water quality by mobilizing dissolved matters like phosphorous from deep to surface waters.
Schleiss, Anton, Boillat, J.-L., De Cesare, G.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Research on Measures to Limit Short-Circuit Current by Renovating the Equipment of the Power Grid

Energies
This paper addresses the increasingly severe issue of exceeding short-circuit current limits brought about by the rapid development of large power grids.
Shuqin Sun, Guanghao Zhou, Zaihua Li, Xiaojun Tang, Yuguang Zhou, Zhenghai Yuan   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source