Results 131 to 140 of about 3,027,054 (295)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Non-efficiency in Automated Markets for the US and Mexico

open access: yesThe Anáhuac Journal
This work analyzes the Efficient Markets Hypothesis (EMH) introduced by Fama (1970). The notion has been a cornerstone in theory and practice in financial markets, given its implications for predicting future prices.
Montserrat Reyna Miranda   +3 more
doaj   +1 more source

Discrete broadly stable distributions

open access: yes
A random variable X is strictly stable if a sum of independent copies of X has the same distribution as X up to scaling, and is stable (in the broad sense) if the sum has the same distribution as X up to both scaling and shifting.
Aldridge, M.
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Strictly operator-stable distributions

open access: yes
Strictly operator-stable distributions are defined and discussed. Characterization of strictly stable distributions with exponent 1 is generalized to strictly ([alpha], Q)-stable distributions with [alpha] being an eigenvalue of Q.infinite divisibility ...
Sato, Ken-iti
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

One dimensional stable distributions are back!

open access: yes, 2017
It has been known for some time that extremal $\alpha$ stable variables ($S_{\alpha}$) are Generalized Gamma Convolutions. Recently, L. Bondesson has shown that the family of GGC distributions is stable by multiplicative convolution.
Fourati, Sonia
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

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