Results 61 to 70 of about 3,027,054 (295)
Age distribution and the stable equivalent [PDF]
AbstractSome populations, like that of the United States in the 1950’s, have a smaller proportion of women of reproductive age than they would ultimately attain with continuance of their age-specific birth and deaths rates, a continuance which produces the condition known in demography as stability. Others, like that of the United States in the 1930’s,
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Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Seismic pulse propagation with constant Q and stable probability distributions
The one-dimensional propagation of seismic waves with constant Q is shown to be governed by an evolution equation of fractional order in time, which interpolates the heat equation and the wave equation.
M. Tomirotti, F. Mainardi
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Domain of Attraction of -stable Distributions under Finite Mixture Models
In this work, we study the asymptotic distribution of the normalized sum of independent, identically distributed random variables under the finite mixture models.
C.E.G. Otiniano, C.R. Gonçalves
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Portfolio optimization with multivariate elliptical stable distributions
Traditional portfolio optimization relies on the assumption that asset returns follow a normal distribution, a premise that fails to capture the heavy tails and skewness commonly observed in financial markets. This study proposes an alternative portfolio
Pérez-Gayo Pedro +2 more
doaj +1 more source
We give some explicit calculations for stable distributions and convergence to them, mainly based on less explicit results in Feller (1971). The main purpose is to provide ourselves with easy reference to explicit formulas and examples. (There are probably no new results.)
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