Results 111 to 120 of about 2,400,643 (255)

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Groundwater recharge mechanisms inferred from isoscapes in a complex tropical mountainous region

Geophysical Research Letters, 2016
Stable isotope variations and groundwater recharge mechanisms remain poorly understood across the tropics, particularly in Central America. Here stable isotopes (δ18O and δ2H) in groundwater, surface water, and rainfall are used to produce high ...
Ricardo Sánchez‐Murillo, Christian Birkel   +1 more
doaj   +1 more source

Nonlinear Quantum Effects Drive Grotthuss Proton Conduction in Structured Electrolytes Based on Deep Eutectic Solvents

Advanced Science, EarlyView.
We demonstrate that the inverse relationship between viscosity and conductivity in structured electrolytes can be circumvented by leveraging their hydrogen bonding networks for Grotthuss proton transport. Using a mixture of imidazole and levulinic acid, we show that the existence of extended hydrogen‐bonded chains that can rapidly reorient result in ...
Benworth B. Hansen, Michael S. Chen, Giselle de A. L. e Souza, Kaylie Glynn, Alan Robledo, Emilia Pelegano‐Titmuss, Katherine Hightower, Miguel Muñoz, Rathiesh Pandian, Clemens Burda, Aikaterini Sanida, Mark Dadmun, Burcu E. Gurkan, Steve G. Greenbaum, Mark E. Tuckerman, Joshua R. Sangoro   +15 more
wiley   +1 more source

Stable-Isotope Bone Chemistry and Human/Animal Interactions in Historical Archaeology

, 2012
Stable isotope–based paleodietary work is ideally suited for answering questions about a wide variety of human/animal relationships in historical archaeological contexts in northeastern North America and farther afield.
Eric J Guiry (9127454), Eric Tourigny (9128960), Stéphane Noël (2647696)   +2 more
core   +4 more sources

Childhood “stress” and stable isotope life‐histories in Transylvania

, 2019
Aims and Objectives Macroscopic skeletal analysis and stable carbon and nitrogen isotope analysis were employed to examine the relationship between skeletal “stress” lesions and changes in the isotopic life history profiles of six nonadults from the ...
Filipek, K.
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Linker‐Locking Strategy for the Rigidification of Flexible Metal–Organic Framework: Structural Stabilization and Controlled ESIPT for H2O/D2O Sensing

Advanced Science, EarlyView.
A linker‐locking strategy rigidifies the flexible metal–organic framework (MOF) MIL‐53‐(OH)2 via the cooperative encapsulation of ligands and structural water. This network significantly enhances the framework's aqueous stability. Crucially, rigidification suppresses enol emission to yield a single keto tautomer state with an extended lifetime ...
Amitosh Sharma, Seonghwan Lee, Seo I Park, Hak‐Won Nho, Junmo Seong, Eunseo Lee, Oh‐Hoon Kwon, Myoung Soo Lah, Jaewoong Lim   +8 more
wiley   +1 more source