Results 151 to 160 of about 312,157 (307)
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
Advanced Science, EarlyView.MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao +7 more
wiley +1 more source
A Perspective on the Applications of Triphasic Gas Storage in Electrochemical Systems
Advanced Science, EarlyView.Gas storage in microporous materials positioned locally at an electrode or electrocatalyst surface enhances electrochemical processes. Abstract Microporous materials store gases under dry conditions (e.g., hydrogen or oxygen via physisorption), but in some cases microporous materials also show triphasic (e.g., in a solid|gas|liquid system) gas storage ...
Zhongkai Li +9 more
wiley +1 more source
Advanced Science, EarlyView.Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng +16 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Advanced Science, EarlyView.A strategy utilizing high‐energy ion beam technology to engineer defects in layered double hydroxide (LDH) nanosheets enables the high loading of non‐noble metal Mo single atoms. The synergistic effect between oxygen vacancies and single atoms promotes a novel mechanism for lattice oxygen activation, thereby significantly enhancing the oxygen evolution
Shixin Wu +9 more
wiley +1 more source
Bulk and Compound-Specific Stable Isotope Analysis for the Authentication of Walnuts (Juglans regia) Origins. [PDF]
J Agric Food Chem, 2023 Athaillah ZA, Yarnes C, Wang SC.
europepmc +1 more source
Advanced Science, EarlyView.A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du +17 more
wiley +1 more source
Stable Isotope Analysis Reveals Habitat-Driven Dietary Niches of <i>Lepus europaeus</i>. [PDF]
Animals (Basel)Balčiauskas L +5 more
europepmc +1 more source
Stable isotope analysis of atmospheric CO2 using a Gasbench II-Cold Trap-IRMS setting. [PDF]
Rapid Commun Mass Spectrom, 2023 Leitner S, Meeran K, Watzinger A.
europepmc +1 more source