Results 171 to 180 of about 4,516,287 (245)
Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System
Annals of Neurology, EarlyView.Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti +17 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Beyond the green solvent paradigm, this review redefines Deep Eutectic Systems (DES) as programmable supramolecular nanoassemblies. We survey their biomedical convergence: stabilizing thermolabile mRNA to enable cold chain‐free logistics, reshaping transdermal microneedle delivery, enabling long‐term wearables via eutectogels, and utilizing Generative ...
Jeesu Moon, Min Seo Kim, Jae‐Seung Lee
wiley +1 more source
Carbon‐Confined Fe3C/Fe3N Janus Interfaces for Selective Nitric Oxide‐to‐Ammonia Electroreduction
Angewandte Chemie, EarlyView.A defect‐rich, graphitic‐carbon‐confined Fe3C/Fe3N Janus catalyst integrates NO transport, adsorption/activation, and interfacial H supply for efficient nitric oxide electroreduction to ammonia. Built from earth‐abundant elements, this architecture enables high‐yield and high‐efficiency NH3 synthesis while valorizing industrial NO emissions.
Jialing Song +10 more
wiley +1 more source
Redox‐Modulated σ‐Bond Reactivity in a Radical‐Anion Dimer
Angewandte Chemie, EarlyView.A radialene‐based radical anion σ‐dimer comprising an elongated C‐C bond exhibits orthogonal stimuli responsiveness. Homolytic cleavage of the dimer to the radical state is triggered by mechanical strain and high temperature. Dimer scission is also achieved via oxidation, resulting in formation of neutral radialenes.
Sushil Ranjan Bhatta +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.Trace Mg doping into gallia–alumina generates hole‐type oxygen species that accelerate hydrogen recombination, eliminating the need for Pt promotion. The fully oxide‐based catalyst resists sintering under repeated regeneration, outperforming benchmark PtSn and CrOx catalysts with exceptional stability over 30 dehydrogenation–regeneration cycles ...
DongHwan Oh +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl +4 more
wiley +1 more source
Spin‐Polarized Interfaces Redirect CO2 Reduction From CO to Formate
Angewandte Chemie, EarlyView.The chiral electrocatalyst exploits the CISS effect to establish a spin‐polarized interface that selectively promotes formate production during CO2 reduction while effectively suppressing the competing hydrogen evolution. ABSTRACT Achieving high product selectivity in electrocatalytic carbon dioxide reduction (CO2RR) remains a critical challenge due to
Fan He +4 more
wiley +1 more source
Water‐Derived Radical Species Initiate Six‐Electron Oxidation of Cyclic Ketones in Microdroplets
Angewandte Chemie, EarlyView.Spontaneous six‐electron oxidation of cyclic ketones to yield dicarboxylic acids/keto acids is achieved in ethanol microdroplets containing about 2% water under ambient conditions without any metal salts, acids, or oxidants. Mechanistic studies show that trace amounts of water and molecular oxygen serve as active oxidants in this transformation ...
Muhammad Mujahid Ali +3 more
wiley +1 more source
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie, EarlyView.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +1 more source
Structural and Functional Siderophore Remodeling by Enzymatic Delipidation
Angewandte Chemie, EarlyView.A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog +5 more
wiley +1 more source