Background: The natural ratios of carbon (C), nitrogen (N), and sulfur (S) stable isotopes can be varied in some specific living organisms owing to various isotopic fractionation processes in nature.
Ill-Min Chung +5 more
doaj +1 more source
To understand the effect of thermochemical sulphate reduction (TSR) on the stable carbon isotopes of light hydrocarbons (LHs) associated with natural gas, 15 gases with varying H2S content from Ordovician reservoir of the Tazhong gas field (TZ-I) in ...
Guoyi Hu +6 more
doaj +1 more source
Measurement of calcium isotopes (δ44Ca) using a multicollector TIMS technique [PDF]
We propose a new“multicollector technique” for the thermal ionization mass spectrometer (TIMS) measurement of calcium (Ca) isotope ratios improving average internal statistical uncertainty of the 44Ca/40Ca measurements by a factor of 2–4 and average ...
Bock, Barbara +5 more
core +1 more source
Simultaneous δ15N, δ13C and δ34S measurements of low-biomass samples using a technically advanced high sensitivity elemental analyzer connected to an isoptope ratio mass spectrometer [PDF]
Conventional simultaneous CNS stable isotope abundance measurements of solid samples usually require high sample amounts, up to 1 mg carbon, to achieve exact analytical results.
Barnes +29 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase
The aim of this study was to investigate the possible existence and magnitude of stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). The catalytic portion of HMGR was expressed and purified.
Svena M. Lüdke +3 more
doaj +1 more source
Legacy pollutants are declining in Great Skuas (Stercorarius skua) but remain higher in Faroe Islands than in Scotland [PDF]
To monitor environmental pollutants in Faroese biota, samples from a top predator were analysed and put into a spatial and temporal context. Analysis of 20 Great Skua eggs sampled in 2012 from the Faroe Islands showed >70 % lower concentrations of ...
Alonso, Sarah +5 more
core +2 more sources
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source

