Stable Isotope Tracer Analysis in Isolated Mitochondria from Mammalian Systems [PDF]
Metabolites, 2014 Mitochondria are a focal point in metabolism, given that they play fundamental roles in catabolic, as well as anabolic reactions. Alterations in mitochondrial functions are often studied in whole cells, and metabolomics experiments using 13C-labeled ...
Simon-Pierre Gravel +3 more
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Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics [PDF]
Metabolites, 2020 Stable isotope-resolved metabolomics (SIRM) is a powerful tool for understanding disease. Advances in SIRM techniques have improved isotopic delivery and expanded the workflow from exclusively in vitro applications to in vivo methodologies to study ...
Holden C. Williams +6 more
doaj +3 more sources
Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology [PDF]
Journal of Lipid and Atherosclerosis, 2020 Like other bodily materials, lipids such as plasma triacylglycerol, cholesterols, and free fatty acids are in a dynamic state of constant turnover (i.e., synthesis, breakdown, oxidation, and/or conversion to other compounds) as essential processes for ...
Il-Young Kim +3 more
doaj +3 more sources
Bioequivalence assessment of high-capacity polymeric micelle nanoformulation of paclitaxel and Abraxane® in rodent and non-human primate models using a stable isotope tracer assay. [PDF]
Biomaterials, 2021 The in vivo fate of nanoformulated drugs is governed by the physicochemical properties of the drug and the functionality of nanocarriers. Nanoformulations such as polymeric micelles, which physically encapsulate poorly soluble drugs, release their ...
Hwang D +13 more
europepmc +2 more sources
Distinguishing Pharmacokinetics of Marketed Nanomedicine Formulations Using a Stable Isotope Tracer Assay. [PDF]
ACS Pharmacol Transl Sci, 2020 The pharmacokinetics of nanomedicines are complicated by the unique dispositional characteristics of the drug carrier. Most simplistically, the carrier could be a solubilizing platform that allows administration of a hydrophobic drug.
Skoczen SL +6 more
europepmc +2 more sources
Ileal digestibility of intrinsically labeled hen's egg and meat protein determined with the dual stable isotope tracer method in Indian adults. [PDF]
Am J Clin Nutr, 2018 Background Protein quality assessment through the Digestible Indispensable Amino Acid Score requires accurate measurements of true ileal protein and amino acid digestibility, for which a dual isotope technique was recently developed.
Kashyap S +7 more
europepmc +2 more sources
Amyloid-β Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity. [PDF]
Front Neurol, 2018 Alzheimer’s disease (AD) is a neurodegenerative disorder with clinical manifestations of progressive memory decline and loss of executive function and language.
Wildburger NC +13 more
europepmc +2 more sources
Preclinical Bioavailability Assessment of a Poorly Water-Soluble Drug, HGR4113, Using a Stable Isotope Tracer [PDF]
Pharmaceutics, 2023 Drug solubility limits intravenous dosing for poorly water-soluble medicines, which misrepresents their bioavailability estimation. The current study explored a method using a stable isotope tracer to assess the bioavailability of drugs that are poorly ...
Eun Ji Ha +5 more
doaj +2 more sources
Experimental Physiology, 2020 What is the topic of this review? This review discusses the application of new stable isotope tracer techniques in understanding the control of skeletal muscle mass. What advances does it highlight?
Daniel J Wilkinson, Matthew S Brook
exaly +2 more sources
24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study. [PDF]
Clin Nutr, 2017 Background & aims The reference method to study protein and arginine metabolism in critically ill children is measuring plasma amino acid appearances with stable isotopes during a short (4–8h) time period and extrapolate results to 24-hour.
de Betue CTI +6 more
europepmc +2 more sources