Results 101 to 110 of about 2,139,344 (304)

Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics

Journal of Lipid Research, 2007
To gain insight into the mechanisms regulating plasma lipid homeostasis, FFA, VLDL-triglyceride (TG), and VLDL-apolipoprotein B-100 (apoB-100) kinetics are commonly assessed using stable isotope-labeled tracer methods.
Magkos Faidon, Bruce W. Patterson, Mittendorfer Bettina   +2 more
doaj   +1 more source

Separation of postprandial lipoproteins: improved purification of chylomicrons using an ApoB100 immunoaffinity method

Journal of Lipid Research, 2020
Elevated levels of triglyceride-rich lipoproteins (TRLs), both fasting and postprandial, are associated with increased risk for atherosclerosis. However, guidelines for treatment are defined solely by fasting lipid levels, even though postprandial lipids
Grace Marie Jones, Russell Caccavello, Sergiu P. Palii, Clive R. Pullinger, John P. Kane, Kathleen Mulligan, Alejandro Gugliucci, Jean-Marc Schwarz   +7 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

A Three component Hydrograph Separation with Stable Isotopes Based on Constrained Least Square Method—A Case Study of Hailuogou Glacier

工程科学与技术, 2016
:Constrained least square method(LSM) was introduced to conduct three or more components hydrograph separation with stable isotopes considering that just one tracer was needed,while more than one independent tracers were required by end member mixing ...
胡立春, 刘国东, 李世钰, 王亮, 孟玉川   +4 more
doaj  

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Using DIMet for Differential Analysis of Labeled Metabolomics Data: A Step-by-step Guide Showcasing the Glioblastoma Metabolism

Bio-Protocol
Stable-isotope resolved metabolomics (SIRM) is a powerful approach for characterizing metabolic states in cells and organisms. By incorporating isotopes, such as 13C, into substrates, researchers can trace reaction rates across specific metabolic ...
Johanna Galvis, Joris Guyon, Thomas Daubon, Macha Nikolski   +3 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Understanding and Regulating C–N Coupling Pathways for Electrocatalytic Urea Synthesis From CO2 and NO3−/NO2−

Advanced Science, EarlyView.
Understanding and regulating C–N coupling is central to electrocatalytic urea synthesis from CO2 and NO3−/NO2−. This review outlines representative coupling pathways, summarizes carbon‐ and nitrogen‐side intermediate regulation strategies, and highlights in situ/operando tools for mechanistic clarification and catalyst design. ABSTRACT Electrocatalytic
Xingbao Chen, Zhuo Li, Lebin Cai, Paul Kilmartin, Bao Yu Xia, Ziyun Wang   +5 more
wiley   +1 more source

Restoration of deuterium marker for multi-isotope mapping of cellular metabolic activity

Scientific Reports
Investigation of cellular metabolic activity with stable-isotope probing (SIP) implies the admittance of an isotope tracer into the metabolic pathway.
Nadiia Yamborko, Laura Schwab, Lubos Polerecky, Yalda Davoudpour, Hugo Berthelot, Niculina Musat, Kim Milferstedt, Jérôme Hamelin, Hans-Hermann Richnow, Carsten Vogt, Hryhoriy Stryhanyuk   +10 more
doaj   +1 more source

Measuring terrestrial fluxes of methyl chloride and methyl bromide using a stable isotope tracer technique

, 2003
Atmospheric methyl chloride (CH3Cl) and methyl bromide (CH3Br), compounds involved in the destruction of stratospheric ozone, are simultaneously produced and consumed by the terrestrial biosphere.
R. Rhew, M. Aydin, E. Saltzman
semanticscholar   +1 more source