Results 121 to 130 of about 77,269 (309)

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Population-Level Metrics of Trophic Structure Based on Stable Isotopes and Their Application to Invasion Ecology

, 2012
PMCID: PMC3283663This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Jackson, MC, M. C. Jackson (2929578), Harper David M., Andrew L Jackson, I. Donohue (7604609), Britton J. Robert, Grey, Jonathan, Ian Donohue, Jackson Andrew L., Harper, DM, Britton, J. Robert, Donohue Ian, J. R. Britton (7604615), Jackson, Michelle C, Donohue, I, Jonathan Grey, Jackson, Andrew L, Jackson Michelle C., J Robert Britton, Harper, David, Grey, J, A. L. Jackson (7604612), David M Harper, Grey Jonathan, J. Grey (7604606), Donohue, Ian, Jackson, AL, D. M. Harper (7604618), Michelle C Jackson, Britton, JR   +29 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Climate and landscape control of runoff stable isotopes in the inland mountain

Journal of Hydrology: Regional Studies
Study region: The Xiying River Basin is a typical inland mountainous watershed located in the Qilian Mountains. Study focus: This article reveals the change of runoff stable isotopes and their control mechanisms based on isotope data of different water ...
Xinrui Lin, Guofeng Zhu, Dongdong Qiu, Linlin Ye, Yuwei Liu, Yinying Jiao, Lei Wang, Kailiang Zhao, Wenhao Zhang, Jiawei Liu, Qinqin Wang   +10 more
doaj   +1 more source

Modelling stable water isotopes: Status and perspectives

EPJ Web of Conferences, 2010
Modelling of stable water isotopes H2 18O and HDO within various parts of the Earth’s hydrological cycle has clearly improved our understanding of the interplay between climatic variations and related isotope fractionation processes.
Werner M.
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Stable isotopes and sedimentology of core GeoB1035

, 2001
Stable isotopes and sedimentology of core ...
Gerold Wefer (6958886), Peter J Müller (6959537), Bickert, Torsten, Torsten Bickert (6958880), Müller, Peter J, Wefer, Gerold   +5 more
core   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Stable isotopes and sedimentology of core GeoB1034

, 2009
Stable isotopes and sedimentology of core ...
Gerold Wefer (6958886), Peter J Müller (6959537), Bickert, Torsten, Torsten Bickert (6958880), Müller, Peter J, Wefer, Gerold   +5 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source