Results 111 to 120 of about 226,366 (293)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Climate and landscape control of runoff stable isotopes in the inland mountain

Journal of Hydrology: Regional Studies
Study region: The Xiying River Basin is a typical inland mountainous watershed located in the Qilian Mountains. Study focus: This article reveals the change of runoff stable isotopes and their control mechanisms based on isotope data of different water ...
Xinrui Lin, Guofeng Zhu, Dongdong Qiu, Linlin Ye, Yuwei Liu, Yinying Jiao, Lei Wang, Kailiang Zhao, Wenhao Zhang, Jiawei Liu, Qinqin Wang   +10 more
doaj   +1 more source

Discovery of Yttrium, Zirconium, Niobium, Technetium, and Ruthenium Isotopes

, 2011
Currently, thirty-four yttrium, thirty-five zirconium, thirty-four niobium, thirty-five technetium, and thirty-eight ruthenium isotopes have been observed and the discovery of these isotopes is discussed here.
A. Nystrom, Ahrens, Antman, Arlt, Arlt, Asghar, Aston, Aston, Aston, Aston, Aston, Aston, Aten, Audi, Baró, Berg, Bernas, Bernas, Bohr, Born, Boyd, Boyd, Brady, Burgus, Butement, Butement, Cacciapuoti, Caretto Jr., Cheifetz, Clarke, De Jesus, De Vries, Della Negra, Delsasso, Deprun, Diamond, Doron, Doron, Dostrovsky, Downing, Dubridge, Duffield, Edwards, Eggen, Eidens, Ewald, Flegenheimer, Flegenheimer, Flegenheimer, Flegenheimer, Flegenheimer, Franz, Fritze, Ginepro, Glendenin, Glendenin, Goriely, Graefenstedt, Grawe, Griffiths, Grosse, Grummitt, Grummitt, Grüter, Gugelot, Gugelot, Gujrathi, Gunther, Götte, Hagberg, Hahn, Hahn, Hahn, Hahn, Hahn, Hahn, Hayden, Heiguchi, Helmholz, Hencheck, Hollander, Hopkins, Hopkins, Hotchkis, Huang, Hyde, Hübenthal, Hübenthal, Iafigliola, Jacobson, Janas, John, Kaba, Katcoff, Katcoff, Katcoff, Kienle, Knight, Korschinek, Korteling, Kundu, Kundu, Kuroyanagi, Lederer, Lederer, Leino, Liang, Lieber, Lister, Lister, Livingood, Livingood, Löbner, M. Thoennessen, Maurer, Maxia, Motta, Motta, Motta, Mukai, Nieckarz, Nishina, Ohnishi, Orth, Pecher, Penttilä, Perrier, Perrier, Pfeiffer, Pool, Riccato, Richardson, Robertson, Rudolph, Rykaczewski, Sagane, Sagane, Sagane, Seaborg, Seaborg, Seaborg, Seelmann–Eggebert, Segre, Selikson, Shizuma, Shizuma, Steinberg, Stewart, Stewart, Strominger, Sullivan, Takahashi, Thoennessen, Trautmann, Trautmann, Troutner, Vallis, Van der Wiel, Van Lieshout, Von Baeckmann, Votsilka, Watson, Wiles, Wohn, Yennello, Yu, Zaitseva, Zhou, Zingales, Äystö, Äystö   +170 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Modelling stable water isotopes: Status and perspectives

EPJ Web of Conferences, 2010
Modelling of stable water isotopes H2 18O and HDO within various parts of the Earth’s hydrological cycle has clearly improved our understanding of the interplay between climatic variations and related isotope fractionation processes.
Werner M.
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

Silicon isotopes as a tracer for silicate utilization in the Peruvian upwelling [PDF]

, 2011
EGU2011-6081 Natural stable isotopes are a powerful tool in marine sciences to investigate biological processes, such as present and past nutrient utilization.
Ehlert, Claudia, Frank, Martin, Grasse, Patricia, Ryabenko, Evgeniya   +3 more
core  

Nanoarchitectonics of Porous Carbons Templated by Inorganic Metal Oxides and Alkali Metal Salts for Energy and Environmental Applications

Advanced Science, EarlyView.
This review explores inorganic metal oxides and metal salt nanoparticles templated porous carbons, highlighting their synthesis, structural features, and performance in energy and environmental applications. It critically compares template types, porosity control, and functional outcomes across recent literature.
Gurwinder Singh, Jibi Kunjumon, Harleen Kaur, Narinder Singh, Gregory Franklin, Arpita Pandey Tiwari, Lukas Van Zweiten, John Kennedy, Ajayan Vinu   +8 more
wiley   +1 more source