Results 161 to 170 of about 15,512,775 (299)

Integrating Biomimetic Reasoning Into Early-Stage Design Thinking for Sustainable Textile Development. [PDF]

Biomimetics (Basel)
Gerolimos N, Kiskira K, Sfyroera E, Tsoumas J, Alevizos V, Plakantonaki S, Foka M, Priniotakis G.   +7 more
europepmc   +1 more source

Sound check, stage design and screen plot - how to increase the comparability of fear conditioning and fear extinction experiments. [PDF]

Psychopharmacology (Berl), 2019
Wotjak CT.
europepmc   +1 more source

DATABASE DESIGN STAGES

This article discusses the main stages of database design and their importance  in the development of modern information systems. The study analyzes conceptual,  logical, and physical design approaches and highlights their role in ensuring efficient data management.
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Parametric Synthesis of Single-Stage Lattice-Type Acoustic Wave Filters and Extended Multi-Stage Design. [PDF]

Micromachines (Basel)
Tseng WH, Wu RB.
europepmc   +1 more source

Two-stage design for phase I-II cancer clinical trials using continuous dose combinations of cytotoxic agents. [PDF]

J R Stat Soc Ser C Appl Stat, 2019
Tighiouart M.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A two-stage design with two co-primary endpoints. [PDF]

Contemp Clin Trials Commun, 2015
Song JX.
europepmc   +1 more source

The Design of Staged Contracting [PDF]

SSRN Electronic Journal, 2017
Albert H. Choi, George G. Triantis
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source