Results 171 to 180 of about 15,512,775 (299)
A Rescue Strategy for Handling Unevaluable Patients in Simon's Two Stage Design. [PDF]
PLoS One, 2015 Belin L, Broët P, De Rycke Y.
europepmc +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
A two-stage design for phase II trials with time-to-event endpoint using restricted follow-up. [PDF]
Contemp Clin Trials Commun, 2017 Belin L, De Rycke Y, Broët P.
europepmc +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Two-stage design for phase II oncology trials with relaxed futility stopping. [PDF]
Stat Interface, 2016 Ivanova A, Deal AM.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The two-stage stroyboarding experience design method
, 2015 Design practitioners and researchers acknowledge the benefits of using graphical representations and storyboards to communicate and elaborate designs.
Michailidou, Ioanna; Haid, Charlotte; Gebauer, Cornelia; Lindemann, Udo
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Sample size reassessment for a two-stage design controlling the false discovery rate. [PDF]
Stat Appl Genet Mol Biol, 2015 Zehetmayer S, Graf AC, Posch M.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
A robust two-stage design identifying the optimal biological dose for phase I/II clinical trials. [PDF]
Stat Med, 2017 Zang Y, Lee JJ.
europepmc +1 more source