Results 91 to 100 of about 5,232,194 (236)

Osimertinib: A Game-Changer in Stage IV EGFR-Driven Lung Cancer

Acta Médica Portuguesa
Lung cancer has a high mortality rate; however, treatment with tyrosine kinase inhibitors targeting specific molecular alterations has significantly improved the survival of patients with advanced or metastatic non-small cell lung carcinoma (NSCLC ...
Sofia Silva, Joana Duarte, Carla Simão, Margarida Felizardo   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Stage IV work hardening in cubic metals [PDF]

, 1986
The work hardening of fcc metals at large strains is discussed with reference to the linear stress-strain behavior often observed at large strains and known as Stage IV. The experimental evidence shows that Stage IV is a work hardening phenomenon that is
Doherty, R. D., Rollett, A. D., Kocks, U. F.   +2 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Buletin LLDIKTI Wilayah IV volume 20 nomor 1 April 2020

, 2020
Buletin kali ini kali ini menyajikan tema yang cukup kekinian, yaitu gagasan yang diangkat oleh “Mas Menteri”, Nadiem Makarim Kemendikbud yaitu tentang “ Merdeka Belajar, Kampus Merdeka”.
Dharnita, Chandra, Suherman, Uman, Pratiwi, Hevy, Rachmiatie, Atie   +3 more
core  

Stage IV lung adenocarcinoma — complete response and long-term survival

Oncology in Clinical Practice
The article presents the case of a 52-year-old patient (currently 61 years old) diagnosed with stage IIa non-smallcell adenocarcinoma of the left lung. The patient underwent surgical resection with negative margins (R0) and received adjuvant chemotherapy
Monika Żeleźnicka, Joanna Filipow, Filip Grydź, Tomasz Sarosiek   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Long Term Of Implant Restoration In Stage Iv Periodontitis

International Dental Journal
Introduction: This case presents a 10-year follow-up of a patient with generalized stage IV, grade C periodontitis, successfully treated with periodontal and implant therapy, emphasizing the value of a multidisciplinary approach.
Gang Yang, Wenjie Hu, Shuangying Zhou
doaj   +1 more source