Results 1 to 10 of about 1,013,786 (315)

Establishment of a prognostic nomogram for patients with locoregionally advanced nasopharyngeal carcinoma incorporating clinical characteristics and dynamic changes in hematological and inflammatory markers

Frontiers in Oncology, 2022
BackgroundThis study aims to investigate the prognostic value of changes in hematological and inflammatory markers during induction chemotherapy (IC) and concurrent chemo-radiation (CCRT), thus construct nomograms to predict progression free survival ...
Qin Liu, Qin Liu, Lingyu Ma, Lingyu Ma, Huangrong Ma, Li Yang, Li Yang, Zhiyuan Xu, Zhiyuan Xu   +8 more
doaj   +1 more source

PD-L1/pS6 in Circulating Tumor Cells (CTCs) during Osimertinib Treatment in Patients with Non-Small Cell Lung Cancer (NSCLC)

Biomedicines, 2022
The PD-1/PD-L1 axis provides CTCs an escape route from the immune system. Phosphorylation of the ribosomal protein S6 is implicated in the same pathway, following mTOR activation. The aim of the study was to investigate the expression of PD-L1 and pS6 in
Evangelia Pantazaka, Aliki Ntzifa, Argyro Roumeliotou, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Galatea Kallergi   +6 more
doaj   +1 more source

A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer

Frontiers in Oncology, 2022
Background/purposeSevere lymphopenia during pelvic radiotherapy (RT) predicts poor survival in patients with cervical cancer. However, the risk of severe lymphopenia has not been well predicted.
Zhiyuan Xu, Zhiyuan Xu, Li Yang, Li Yang, Hao Yu, Linlang Guo   +5 more
doaj   +1 more source

Replacing 30 Gy in 10 fractions with stereotactic body radiation therapy for bone metastases: A large multi-site single institution experience 2016–2018

Clinical and Translational Radiation Oncology, 2020
Background: Bone metastases cause significant morbidity in patients with cancer, and radiation therapy (RT) is an effective treatment approach. Indications for more complex ablative techniques are emerging.
Erin F. Gillespie, Kaitlyn Lapen, Diana G. Wang, N. Wijetunga, Gerri L. Pastrana, Marisa A. Kollmeier, Josh Yamada, Adam M. Schmitt, Daniel S. Higginson, Max Vaynrub, Ernesto Santos Martin, Amy J. Xu, C. Jillian Tsai, Divya Yerramilli, Oren Cahlon, T. Jonathan Yang   +15 more
doaj   +1 more source

Traditional and novel imaging modalities for advanced prostate cancer: A critical review

Urology Annals, 2023
Accurate detection of metastatic prostate cancer in the setting of preoperative staging as well as posttreatment recurrence is crucial to provide patients with appropriate and timely treatment of their disease.
Spencer Hill, Farzaan Kassam, Sadhna Verma, Abhinav Sidana   +3 more
doaj   +1 more source

Survival for patients with metastatic colon cancer underwent cytoreductive colectomy in the era of rapid development of anticancer drugs: A real-world analysis based on updated population dataset of 2004–2018

Frontiers in Pharmacology, 2022
Objective: Metastatic colon cancer (mCC) poses a great threat to the survival of patients suffering from it. In the past decade, many clinical trials have been carried out to improve the prognosis of patients with mCC.
Guangran Meng, Shengtao Yang, Feixiang Chen   +2 more
doaj   +1 more source

Immunotherapy and Its Timing in Advanced Basal Cell Carcinoma Treatment

Dermatology Practical & Conceptual, 2023
For patients with advanced BCC, including locally advanced or metastatic BCC not amenable to curative surgery or radiotherapy, hedgehog pathway inhibitors (HHI) vismodegib and sonidegib are approved as first-line systemic treatment.
Clio Dessinioti, Alexander Stratigos
doaj   +1 more source

Association of radiation dose intensity with overall survival in patients with distant metastases

Cancer Medicine, 2021
Background Patients with metastatic cancer referred to radiation oncology have diverse prognoses and there is significant interest in personalizing treatment.
Johnny Kao, Mark K. Farrugia, Samantha Frontario, Amanda Zucker, Emily Copel, John Loscalzo, Ashish Sangal, Boramir Darakchiev, Anurag Singh, Symeon Missios   +9 more
doaj   +1 more source

Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2

Cells, 2021
In vitro studies of a disease are key to any in vivo investigation in understanding the disease and developing new therapy regimens. Immortalized cancer cell lines are the best and easiest model for studying cancer in vitro.
Rizwan Ali, Hajar Al Zahrani, Tlili Barhoumi, Alshaimaa Alhallaj, Abdullah Mashhour, Musaad A. Alshammari, Yasser A. Alshawakir, Omar Baz, Abdullah H. Alanazi, Abdul Latif Khan, Hassan Al Nikhli, Mohammed A. Al Balwi, Lolwah Al Riyees, Mohamed Boudjelal   +13 more
doaj   +1 more source

Moonshots and metastatic disease: the need for a multi-faceted approach when studying atypical responses

npj Breast Cancer, 2017
Clinical research generally focuses on results involving a statistical mean with little attention in trial design to patients who respond considerably better or worse than average.
Kristine De La Torre, Elly Cohen, Anne Loeser, Marc Hurlbert, on behalf of the Metastatic Breast Cancer Alliance   +4 more
doaj   +1 more source