Results 101 to 110 of about 1,716,518 (288)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Monitoring corn and soybean crop development by remote sensing techniques [PDF]

open access: yes
A system for spectrally monitoring the stages of crop development for corn and soybeans based upon red and photographic infrared spectral radiances is proposed.
Elgin, J. H., Jr.   +2 more
core   +1 more source

Beyond horizons and stages: A periodization proposal for peruvian archaeology

open access: yesISHRA, Revista del Instituto Seminario de Historia Rural Andina, 2023
The sequential ordering of the social phenomena that occurred throughout Peruvian history is one of the main tasks of historians and archaeologists. In the case of Andean prehistory (ca. 12 000 BC-AD 1532), scholars interested in the past and archaeologists have proposed a series of schemes to organize an infinite number of social phenomena, despite ...
openaire   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Division of Precipitation Stage Based on Optimal Dissection Method:A Case Study in Hefei Station

open access: yesRenmin Zhujiang, 2020
Based on daily precipitation data of Hefei station from 1953 to 2019,this paper divides stages of precipitation in Hefei preliminarily by the optimal dissection method,and identifies the precipitation stages ultimately according to the general ...
HUANG Bingjie   +5 more
doaj  

Frequency reassignment in cellular phone networks [PDF]

open access: yes, 2006
In cellular communications networks, cells use beacon frequencies to ensure the smooth operation of the network, for example in handling call handovers from one cell to another.
Billingham, John   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Impact of PM2.5, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei

open access: yesAnnals of Medicine
Introduction TWe investigated impacts of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5), relative humidity (RH), and temperature on sleep stages and arousal.Materials and Methods A cross-sectional analysis involving 8,611 ...
Nguyen Thanh Tung   +15 more
doaj   +1 more source

The cyclical trend of local public service governance: evidence from urban water management in Spain [PDF]

open access: yes
The level of public and private involvement in economic activity in societies has changed over time. One may talk about the existence of a cyclical trend in which the most important periods of public governance are replaced by periods in which private ...
Alberto Ruiz Villaverde   +2 more
core  

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