Results 111 to 120 of about 1,815,255 (350)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Damage periods of the main diseases occurring in vineyards during the annual development phases [PDF]

E3S Web of Conferences
In the study, the researchers focused on understanding the developmental stages and damage periods of several key pathogens affecting vineyards. Gloeosporium ampelophagum Sacc, Uncinula necator Burrill, Agrobacterium tumefaciens Conn, Plasmopara viticola
Rakhmatov Asror, Kholliev Asamiddin, Tashpulatov Uygun, Haydarova Shahnoza   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Time dependence of solid-particle impingement erosion of an aluminum alloy [PDF]

Erosion studies were conducted on 6061-T6511 aluminum alloy by using jet impingement of glass beads and crushed glass particles to investigate the influence of exposure time on volume loss rate at different pressures.
Buckley, D. H., Veerabhadrarao, P.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VIII: The Eighth Year (2015-2016)

, 2016
Continuing the project described by Kato et al. (2009, arXiv:0905.1757), we collected times of superhump maxima for 128 SU UMa-type dwarf novae observed mainly during the 2015-2016 season and characterized these objects.
Akazawa, Hidehiko, Ando, Kazuko, Andreev, Maksim V., Antipin, Sergey V., Antonyuk, Kirill A., Antonyuk, Oksana I., Babina, Julia V., Baklanov, Aleksei V., Bolt, Greg, Chochol, Drahomir, Cook, Lewis M., de Miguel, Enrique, Debski, Bartomiej, Dubois, Franky, Dubovsky, Pavol A., Dvorak, Shawn, Fukushima, Daiki, Gladilina, Natalia, Goff, William N., Golysheva, Polina, Hambsch, Franz-Josef, Hiraga, Mitsutaka, Hirosawa, Kenji, Horie, Tsuneo, Imada, Akira, Isogai, Keisuke, Itoh, Hiroshi, Kafka, Stella, Kamibetsunawa, Taku, Kasai, Kiyoshi, Kato, Taichi, Katysheva, Natalia, Kimura, Mariko, Kiyota, Seiichiro, Kochanek, Christopher S., Kojiguchi, Naoto, Kudzej, Igor, Logie, Ludwig, Maeda, Yutaka, Matsumoto, Katsura, Miller, Ian, Monard, Berto, Muyllaert, Eddy, Ogi, Minako, Oksanen, Arto, Otani, Noritoshi, Pavlenko, Elena P., Pickard, Roger D., Pit, Nikolaj V., Prieto, Jose L., Rau, Steve, Richmond, Michael, Ruiz, Javier, Sabo, Richard, Schmeer, Patrick, Shappee, Benjamin, Shears, Jeremy, Shugarov, Sergey Yu., Simon, Andrei, Sosnovskij, Aleksei A., Stanek, Krzysztof Z., Starr, Peter, Stein, William, Stone, Geoff, Stubbings, Rod, Sugiura, Yuki, Takeda, Nao, Takigawa, Naoki, Tanabe, Kenji, Tatsumi, Taiki, Tordai, Tamas, Uto, Yusuke, Vanaverbeke, Siegfried, Vanmunster, Tonny, Voloshina, Irina B., Yamada, Eiji, Zaostrojnykh, Anna M., Zubareva, Alexandra M.   +77 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Beyond horizons and stages: A periodization proposal for peruvian archaeology

ISHRA, Revista del Instituto Seminario de Historia Rural Andina, 2023
The sequential ordering of the social phenomena that occurred throughout Peruvian history is one of the main tasks of historians and archaeologists. In the case of Andean prehistory (ca. 12 000 BC-AD 1532), scholars interested in the past and archaeologists have proposed a series of schemes to organize an infinite number of social phenomena, despite ...
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source