Results 81 to 90 of about 1,815,255 (350)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

EXISTENTIAL TRANSFORMATION OF THE TOURIST CENTERS IN ALTAI REGION

Вестник Кемеровского государственного университета, 2015
The paper presents an analysis of the development of tourism in the socio-cultural development of the territory of Altai region, which allowed distinguishing several periods in recreational activities that differ in many ways: the main motive, the number
E. A. Dzagoeva
doaj  

Clinicopathological Characteristics and Prognosis of Papillary Thyroid Carcinoma in Naturally Menopausal Women with Various Durations of Premenarche, Reproductive Periods, and Postmenopausal Stages

International Journal of Endocrinology, 2017
Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients ...
Xuhang Zhu, Bin Yu, Yu-qing Huang, Jing-nan Zhou, Ming-Hua Ge   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Do Frequent Lactation Periods in Laboratory Rat Colonies Have a Negative Effect on Mothers' Care and Feeding of Themselves and Their Offspring?

Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi
Laboratory rats are the second most preferred mammal species in experimental research. Do the frequent lactation periods of the female rats used in production in this study negatively affect the care of the offspring and themselves? For this purpose, the
Abdullah Kumral, Pembe Keskinoğlu, Defne Engür, Canberk Yılmaz, Osman Yılmaz   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Influence of genotype, climatic factors and sowing time on maize yield and water release rate

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
The objective of this paper was to determine the optimal sowing periods for maize in alluvial soil in the semiarid conditions of the southern of Serbia during two successive growing seasons of six maize genotypes from three FAO ripening groups and three
Vera RAJIČIĆ, Jelena STOJILJKOVIĆ, Vera POPOVIĆ, Milan BIBERDŽIĆ, Dragan TERZIĆ, Kristina LUKOVIĆ, Mirela MATKOVIĆ STOJŠIN, Nenad ĐURIĆ   +7 more
doaj   +1 more source

Temporal development of compensation strategies for perturbed palate shape in German /S/-production [PDF]

, 2006
The palate shape of four speakers was changed by a prosthesis which either lowered the palate or retracted the alveoles. Subjects wore the prosthesis for two weeks and were recorded several times via EMA.
Brunner, Jana, Fuchs, Susanne, Hoole, Phil, Perrier, Pascal   +3 more
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