Results 141 to 150 of about 376,984 (269)

Single-model deep learning approach for simultaneous cervical vertebral maturation staging and skeletal jaw relationship on lateral cephalograms using YOLOv8 and CNN. [PDF]

BMC Oral Health
Alotaibi NM, Kamel AM, Khalil AT, Hammad SM.   +3 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Missing Hepatic Dimension in CKM Staging. [PDF]

JACC Adv
Ragozzino G, Mattera E.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Clear Cell Sarcoma of the Kidney Case Reports Should Connect Renal-Origin Imaging With Staging, Treatment Rationale, and Follow-Up. [PDF]

Clin Case Rep
Awan MA, Raza HU.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Diagnostic and Prognostic Applications of PET/CT in Small-cell Lung Cancer. [PDF]

Cancer Diagn Progn
Okada Y, Zama T, Itonaga T, Mikami R, Okubo M, Sugahara S, Wada S, Kawamoto T, Mabuchi Y, Kawaguchi M, Ishida M, Nakai M, Abe K, Yoshimura M, Saito K.   +14 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Pediatric Cardiac Function Staging and Management Recommendations. [PDF]

Pediatr Discov
Pan B, Han L, Zhuang J, Shen X, Mao C, Lin Y, An J, Zhang H, Xie C, Zhang Y, Zhang L, Guo Y, Xiao Y, Yang S, Zhang L, Yuan Y, Sun L, Chen Z, Ding W, Li Y, Li Z, Tian J.   +21 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source